TrxR1 inhibition sensitizes hepatocellular carcinoma to Motesanib via an autophagy-ROS-JNK/ER stress axis [0.03%]
TrxR1抑制通过自噬-ROS-JNK/内质网应激轴增强肝细胞癌对Motesanib的敏感性
Shengwei Du,Peisen Zheng,Wen Li et al.
Shengwei Du et al.
Hepatocellular carcinoma (HCC) remains a highly aggressive malignancy with a dismal prognosis, largely due to the limited effectiveness of current therapeutic interventions. Although Motesanib (MOT) is a clinically studied VEGFR-centered in...
Integrated microbiome-metabolome analysis implicates Acinetobacter guillouiae in arachidonic acid metabolic remodeling and endometrial cancer cell proliferation [0.03%]
整合微生物组-代谢组分析表明不动杆菌属与花生四烯酸代谢重构和子宫内膜癌细胞增殖有关
Wenjing Ma,Jie Pi,Huanzhi Wan et al.
Wenjing Ma et al.
Background: Lesion-associated microbiota have emerged as potential regulators of tumor biology. However, the ecological organization and metabolic relevance of the local endometrial microbiome in endometrial cancer (EC) r...
Comprehensive multi-omics analysis reveals a fatty acid metabolism gene signature for prognostic assessment and immunotherapy in nasopharyngeal carcinoma, and identifies ABCC1 as a potential novel therapeutic target [0.03%]
全面的多组学分析揭示了用于鼻咽癌预后评估和免疫治疗的脂肪酸代谢基因特征，并鉴定ABCC1为潜在的新疗法靶点
Yang Xu,Liru Zhu,Qingqing Zhang et al.
Yang Xu et al.
Background: Nasopharyngeal carcinoma (NPC) is a subtype of head and neck squamous cell carcinoma characterized by high recurrence and metastasis rates and poor prognosis. Although immune checkpoint inhibitors have emerged...
Bovine lactoferrin induces apoptosis and modulates the transcriptomic landscape of HeLa cervical cancer cells [0.03%]
牛乳铁蛋白诱导HeLa宫颈癌细胞凋亡并调节其基因表达谱
Yu Zhao,Rui Liu,Mengtian Li et al.
Yu Zhao et al.
Cervical cancer (CC) remains a leading malignancy among women worldwide. Current management strategies, including surgery, radiotherapy, chemotherapy, targeted therapy, and prevention, often cause significant adverse effects and demonstrate...
Programmed cell death-related gene S100A9 promotes macrophage M1 polarization and chondrocyte apoptosis in rheumatoid arthritis [0.03%]
程序性细胞死亡相关基因S100A9促进类风湿关节炎巨噬细胞M1极化及软骨细胞凋亡
Qingyuan Xu,Jinfu Liu,Qiang Ding et al.
Qingyuan Xu et al.
Background: Rheumatoid arthritis (RA) is a heterogeneous chronic autoimmune disease. Its high disability rate has a serious impact on individuals and society. Programmed cell death (PCD) patterns play a key role in severa...
The role of ESRRA and JUNB in oxyphil cells: insights from spatial transcriptomics and single-cell transcriptomics in uremic secondary hyperparathyroidism [0.03%]
ESRRA和JUNB在嗜酸细胞中的作用：尿毒症继发性二次甲状旁腺功能亢进的空间转录组学和单细胞转录组学的新见解
Zeyu Zhang,Xiangyuan Qiu,Botao Sun et al.
Zeyu Zhang et al.
Oxyphil cells are a primary cellular component of the parathyroid gland. Due to the limitations of techniques for separating oxyphil cells from chief cells, the characteristics and functions of oxyphil cells in uremic secondary hyperparathy...
Tenascin C promotes the formation of abdominal aortic aneurysm by regulating the homeostasis of vascular smooth muscle cells [0.03%]
腱钙蛋白C通过调节血管平滑肌细胞稳态促进腹主动脉瘤的形成
Xiaoyong Xiao,Jie Xiong,Yixuan Bao et al.
Xiaoyong Xiao et al.
Background: Abdominal aortic aneurysm (AAA) is the most common type of arterial dilation disease. Once ruptured and bleeding, AAA can be life-threatening, with a mortality rate as high as 90%. Vascular smooth muscle cells...
Silymarin attenuates diabetic nephropathy in rats via modulation of the miRNA-223/NLRP3/caspase-1/GSDMD axis and inflammasome-related pyroptotic signaling [0.03%]
奶蓟素通过调节miRNA-223/NLRP3/caspase-1/GSDMD轴和与炎性小体相关的焦亡信号减轻糖尿病肾病rats中的病理损伤
Merna G Aboismaiel,Mohamed N Amin,Laila A Eissa
Merna G Aboismaiel
Diabetic nephropathy (DN) is a progressive microvascular complication of diabetes and a leading cause of end-stage renal disease, with limited disease-modifying therapeutic options. DN is characterized by progressive renal dysfunction, oxid...
Deciphering mitotic catastrophe-associated transcriptomic patterns in renal cell carcinoma: prognostic significance and immunotherapy-related associations [0.03%]
解码肾细胞癌有丝分裂灾难相关的转录模式：预后意义和与免疫治疗相关性
Zilin Wang,Xu Hu,Zhiyong Lin et al.
Zilin Wang et al.
Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignancy with complex molecular features. Mitotic catastrophe (MC), a key regulator of cell fate during aberrant mitosis, contributes to tumor progression...
Dongsheng Ni,Zeying Feng,Dehuan Liang et al.
Dongsheng Ni et al.
Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are potent lipid-lowering therapies, however, concerns regarding their neurocognitive safety persist because of conflicting evidence. ...