Medulloblastoma response to mevalonate pathway inhibition is independent of p53 status [0.03%]
髓母细胞瘤对甲羟戊酸通路抑制的反应与p53状态无关
Charley Comer,Christopher Edwards,Sabrina Caporali et al.
Charley Comer et al.
Medulloblastoma (MB) is the most common primary solid paediatric brain tumour. It arises in the cerebellum, the part of the brain responsible for equilibrium and coordination. Molecular profiling has identified four MB subgroups named Wingl...
Isolation and characterization of novel bacteriophages with broad-spectrum lytic activity against carbapenem-resistant Klebsiella pneumoniae capsular pathotypes K1, K2, K3, K5, and K20 [0.03%]
分离并表征新型广谱溶细胞性噬菌体对抗碳青霉烯类抗生素耐药的肺炎克雷伯氏菌荚膜血清型K1、K2、K3、K5和K20的作用机制
Kenneth Ssekatawa,Slawomir Michniewski,Ibrahim Ntulume et al.
Kenneth Ssekatawa et al.
MEF2A activates the ZDHHC20/NF-κB pathway to inhibit doxorubicin sensitivity and promote the malignant progression of acute myeloid leukemia [0.03%]
MEF2A通过激活ZDHHC20/NF-κB通路抑制多柔比星敏感性并促进急性髓系白血病恶性进展
Xi Ming,Wanying Liu,Jiaying Wu et al.
Xi Ming et al.
Background: Acute myeloid leukemia (AML) remains challenging due to chemotherapy resistance and disease relapse. Investigating novel regulators of AML pathogenesis and drug sensitivity is crucial for improving outcomes. M...
In-silico study of machine learning discovers de novo lipogenesis for predicting prognosis and immunotherapy responses in kidney renal clear cell carcinoma [0.03%]
基于机器学习的计算研究发现从头脂质合成可预测肾透明细胞癌预后及免疫治疗反应
Dongze Liu,Weiyang Liu,Bo Han et al.
Dongze Liu et al.
SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation [0.03%]
SIRT1半倍体不足通过精子α-微管蛋白过度乙酰化再现年龄相关的生育力下降
María Iniesta-Cuerda,Iveta Valentova,Jiří Moravec et al.
María Iniesta-Cuerda et al.
Advanced paternal age compromises male fertility and correlates to a decline of the deacetylase SIRT1 activity, a central regulator of germline homeostasis and chromatin dynamics. Acetylation imbalance has been pointed out as a driver of te...
FAM83D facilitates EMT and metastasis of cervical cancer via interaction with GSK3β and inactivation of GSK3β/stabilization of Snail signaling [0.03%]
FAM83D通过与GSK3β的相互作用促进宫颈癌上皮间质转化和转移及抑制GSK3β/稳定Snail信号通路
Jiaofeng Li,Fengtian Li,Xia Meng et al.
Jiaofeng Li et al.
PHGDH mediated serine biosynthesis metabolism suppresses vascular calcification [0.03%]
天冬氨酸激酶介导的serine生物合成代谢抑制血管钙化
Liao Tan,Jie Liu,Ruizheng Shi et al.
Liao Tan et al.
The APC/C subunit APC7 promotes hepatocellular carcinoma progression by mediating ubiquitination and degradation of LATS1 to activate YAP/TAZ [0.03%]
APC/C亚基APC7通过介导LATS1的泛素化降解来激活YAP/TAZ促进肝细胞癌进展
Ying Sun,Renyu Zhang,Yilin Guo et al.
Ying Sun et al.
Incomplete radiofrequency ablation may elicit pro-oncogenic effects in thyroid cancer cells in a xenograft mouse model [0.03%]
不完全射频消融可通过异种移植裸鼠模型诱发甲状腺癌细胞的促致癌作用
Chi-Yu Kuo,Yi-Chiung Hsu,Ying-Syuan Li et al.
Chi-Yu Kuo et al.
Nano gold-loaded Nannochloropsis oculata attenuates fluoride-induced neural and hepatorenal toxicity by modulating the Nrf2/NF-κB axis and aquaporins [0.03%]
负载纳米金的微拟甲藻通过调节Nrf2/NF-κB轴和水通道蛋白减轻氟引起的神经毒性、肝肾毒性
Kholoud K Emam,Obeid Shanab,Nuha Anajirih et al.
Kholoud K Emam et al.