Single-cell RNA sequencing analysis reveals the evolution and regulatory features of specialized endothelial cell subsets in non-traumatic osteonecrosis of the femoral head [0.03%]
单细胞RNA测序分析揭示股骨头非创伤性缺血性坏死血管病变的内皮细胞亚群及其调控特征
Shengping Tang,Hongyi Lu,Xinda Zheng et al.
Shengping Tang et al.
Non-traumatic osteonecrosis of the femoral head (NONFH) is a disabling disease mainly caused by glucocorticoid use and alcohol abuse, characterized by local impairment of blood supply and limited bone repair; however, the composition and re...
METTL16 promotes MASLD progression through the regulation of lipid synthesis and immune response [0.03%]
METTL16通过调节脂质合成和免疫反应促进MASLD进展
Guixin Li,Long Wang,Li Zhang et al.
Guixin Li et al.
Background: Methyltransferase-like 16 (METTL16) is a recently identified m6A RNA methyltransferase. Although its role in hepatocellular carcinoma has been explored, its function in metabolic dysfunction-associated steatot...
NSDHL as a regulator of lipid peroxidation and ER stress-mediated apoptosis in ovarian cancer [0.03%]
NSDHL对卵巢癌中脂质过氧化和内质网应激介导的细胞凋亡的调控作用
Xu Shanshan,Ran Jinshi,Cai Wanlin et al.
Xu Shanshan et al.
TYMP upregulation mediated by the hyperactivated IL-17/NF-κB1 axis promotes psoriasis through enhancing aberrant keratinization and neutrophil-mediated inflammation [0.03%]
活化的IL-17/NF-κB1轴介导的TYMP上调通过促进异常角化和中性粒细胞介导的炎症从而促进银屑病发展
Jing Wang,Zeng Zhou,Yanyan Chen et al.
Jing Wang et al.
Psoriasis is a common, chronic, and recurrent immune-mediated disorder with global prevalence, underscoring the need for novel biomarkers to improve diagnosis and treatment. In this study, differentially expressed genes (DEGs) in psoriatic ...
Identification and functional validation of mitochondria-related genes associated with tubular injury in kidney transplantation and ischemia-reperfusion injury [0.03%]
肾脏移植和缺血再灌注损伤相关管腔损伤的线粒体关系基因的鉴定及其功能验证
Boqing Dong,Huanjing Bi,Chongfeng Wang et al.
Boqing Dong et al.
PLIN3 overexpression in lung adenocarcinoma promotes M2 macrophage-myofibroblast transition in the tumor microenvironment [0.03%]
肺腺癌中PLIN3过表达通过促进肿瘤微环境中的M2型巨噬细胞肌成纤维细胞转变促进癌症进展
Kang Tian,Guoyuan Ma,Deyu Guo et al.
Kang Tian et al.
Exploring the intersection between necromass reutilization and genome protection reveals novel proteins that contribute to both processes in Ustilago maydis [0.03%]
探究 undeadmass 再利用与基因组保护之间的关系揭示了两类均能参与上述两种过程的新型蛋白质：以Ustilago maydis 为例
Stefan Stanovcic,Mira Milisavljevic,Stoimir Kolarevic et al.
Stefan Stanovcic et al.
Background: Recovery of microbial populations following severe stress and extensive loss of viability-termed RUS (repopulation upon shattering)-represents a fundamental biological challenge. Successful RUS depends on the ...
MiR-142-3p promotes radioresistance by targeting FOXO4 in colorectal cancer [0.03%]
MicroRNA-142-3p通过靶向FOXO4促进结直肠癌的放疗抵抗性
Xi Wang,Wei-Xi Hua,Ying Liu et al.
Xi Wang et al.
Abstract: Radiation therapy (RT) is one of the most important strategies for killing cancer cells and shrinking tumors. However, in colorectal cancer, the application of radiotherapy is restricted due to radioresistance. ...
Plasma metabolomic profiling identifies a metabolic signature for non-muscle-invasive bladder cancer independent of hematuria [0.03%]
无血尿的非肌层浸润性膀胱癌代谢特征的发现
Roberto Speziale,Valerio Iacovelli,Guido Leoni et al.
Roberto Speziale et al.
Background: Non-muscle-invasive bladder cancer (NMIBC) accounts for approximately 75% of bladder cancer cases and, despite a generally favorable prognosis, requires lifelong cystoscopic surveillance, resulting in substant...
DLAT inhibits ferroptosis to promote malignant progression of gastric cancer through Nrf2/HO-1/GPX4 signaling pathway [0.03%]
DLAT通过Nrf2/HO-1/GPX4信号通路抑制铁死亡以促进胃癌恶性进展
Lin Li,Hongjing Zhao,Xiaoping Niu et al.
Lin Li et al.