Causal graph-based analysis of genome-wide association data in rheumatoid arthritis [0.03%]
基于因果图的类风湿关节炎全基因组关联数据的分析
Alexander V Alekseyenko,Nikita I Lytkin,Jizhou Ai et al.
Alexander V Alekseyenko et al.
Background: GWAS owe their popularity to the expectation that they will make a major impact on diagnosis, prognosis and management of disease by uncovering genetics underlying clinical phenotypes. The dominant paradigm in...
Why eukaryotic cells use introns to enhance gene expression: splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity [0.03%]
内含子通过抑制拓扑异构酶I切割活性来减少转录相关突变从而增强真核细胞基因表达的原因
Deng-Ke Niu,Yu-Fei Yang
Deng-Ke Niu
Background: The costs and benefits of spliceosomal introns in eukaryotes have not been established. One recognized effect of intron splicing is its known enhancement of gene expression. However, the mechanism regulating s...
MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival [0.03%]
微小核糖核酸在多发性骨髓瘤中的表达与遗传亚型、等位基因和生存率相关
Jianxiang Chi,Erica Ballabio,Xiao-He Chen et al.
Jianxiang Chi et al.
Background: MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including hematological malignancies. However, the role of microRNAs in the pat...
Rodrigo J S Dalmolin,Mauro A A Castro,José L Rybarczyk Filho et al.
Rodrigo J S Dalmolin et al.
Background: Genetic plasticity may be understood as the ability of a functional gene network to tolerate alterations in its components or structure. Usually, the studies involving gene modifications in the course of the e...
Statistical methods for detecting periodic fragments in DNA sequence data [0.03%]
检测DNA序列数据中周期片段的统计方法
Julien Epps,Hua Ying,Gavin A Huttley
Julien Epps
Background: Period 10 dinucleotides are structurally and functionally validated factors that influence the ability of DNA to form nucleosomes, histone core octamers. Robust identification of periodic signals in DNA sequen...
Emmanuil E Shnol,Elena A Ermakova,Alexey S Kondrashov
Emmanuil E Shnol
Background: Operation of natural selection can be characterized by a variety of quantities. Among them, variance of relative fitness V and load L are the most fundamental. ...
Aurélie Hua-Van,Arnaud Le Rouzic,Thibaud S Boutin et al.
Aurélie Hua-Van et al.
Transposable elements (TEs) were first discovered more than 50 years ago, but were totally ignored for a long time. Over the last few decades they have gradually attracted increasing interest from research scientists. Initially they were vi...
Functional analysis of archaeal MBF1 by complementation studies in yeast [0.03%]
利用酵母回补实验对古菌MBF1的功能进行分析
Jeannette Marrero Coto,Ann E Ehrenhofer-Murray,Tirso Pons et al.
Jeannette Marrero Coto et al.
Background: Multiprotein-bridging factor 1 (MBF1) is a transcriptional co-activator that bridges a sequence-specific activator (basic-leucine zipper (bZIP) like proteins (e.g. Gcn4 in yeast) or steroid/nuclear-hormone rec...
Do clones degenerate over time? Explaining the genetic variability of asexuals through population genetic models [0.03%]
无性繁殖者的遗传变异通过群体遗传模型解释：克隆累积不利突变还是纯化选择？
Karel Janko,Pavel Drozd,Jan Eisner
Karel Janko
Background: Quest for understanding the nature of mechanisms governing the life span of clonal organisms lasts for several decades. Phylogenetic evidence for recent origins of most clones is usually interpreted as proof t...
The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon [0.03%]
一个衍生界的起源：一颗革兰氏阳性菌如何穿越沙漠成为一个古菌
Ruben E Valas,Philip E Bourne
Ruben E Valas
Background: The tree of life is usually rooted between archaea and bacteria. We have previously presented three arguments that support placing the root of the tree of life in bacteria. The data have been dismissed because...