Glabridin improves cardiac remodeling after myocardial infarction by activating PPARγ to regulate the ubiquitination and degradation of EGFR [0.03%]
姜黄素类似物姜辣素通过激活PPARγ调节EGFR泛素化及降解改善心肌梗死后的心室重构
Zixuan Li,Yiran Hu,Yu Jiang et al.
Zixuan Li et al.
Activation of the TGR5/cAMP/PKA/CREB axis in cholangiocytes mediates epithelial-mesenchymal transition and fibrosis in hepatolithiasis [0.03%]
TGR5/cAMP/PKA/CREB轴在胆管细胞中的激活介导肝内胆泥淤积症中上皮间质转化及纤维化
Dan Tang,Jiali Yang,Xinhao Shi et al.
Dan Tang et al.
Exosomes from tumor-associated macrophages promote glycolysis and malignant NSCLC progression by delivery of hsa_circ_0000896 [0.03%]
肿瘤相关巨噬细胞来源的外泌体通过递送hsa_circ_0000896促进非小细胞肺癌糖酵解及恶性进展
Jiao Liu,Qianqian Cai,Gang Huang et al.
Jiao Liu et al.
CircAFF4 inhibits lung cancer progression via destabilizing GPX4 and triggering ferroptosis [0.03%]
CircAFF4通过降低GPX4的稳定性并诱导铁死亡来抑制肺癌进展
Jianing Wang,Sicheng Xin,Chuanfeng Zhang et al.
Jianing Wang et al.
Inhibition of circZFX suppresses malignant phenotypes in cholangiocarcinoma via the miR-654-3p/HDGF and YAP1 signaling activation [0.03%]
circZFX通过miR-654-3p/HDGF和YAP1信号激活抑制胆管癌恶性表型
Tingming Liang,Chengxuan Gong,Xinbing Yang et al.
Tingming Liang et al.
The B7 family subgroup reflects tumor cell heterogeneity and patient post-operative prognosis in gallbladder cancer [0.03%]
BD家族亚组反映胆囊癌细胞异质性和患者的术后预后
Chuhan Ma,Huixin Hu,Yang Li et al.
Chuhan Ma et al.
Purpose: To elucidate the biological heterogeneity of gallbladder cancer (GBC) cells and refine post-operative risk stratification by investigating the expression and downstream signaling of the B7-family immune checkpoin...
m5C RNA modification in gastrointestinal cancers: a comprehensive review from molecular mechanism to clinical implication [0.03%]
胃肠道癌症中的m5C RNA修饰：从分子机制到临床意义的全面综述
Chao Xu,Qinwen Ye,Hao Wang et al.
Chao Xu et al.
Prenatal bisphenol A exposure perturbs sex-dependent transcriptomic regionalization of autism-associated genes in the developing brain [0.03%]
产前双酚A暴露会干扰自闭症相关基因在发育大脑中的性别依赖性转录区域化
Suporn Sukjamnong,Thanit Saeliw,Pawinee Panjabud et al.
Suporn Sukjamnong et al.
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication, social interaction, and behavioral regulation. Its etiology arises from a combination of genetic vuln...
Gene-guided repurposing identifies dihydroergotamine as a candidate inhibitor of the BCL2-SIVA1 axis in advanced gastric cancer in vitro [0.03%]
基因指导的再定位发现二氢麦角胺可能作为胃癌中BCL2-SIVA1轴抑制剂
Yu-Liang Huang,Zhi-Xing Lu,Zheng-Yi Shi et al.
Yu-Liang Huang et al.
Dapagliflozin induces renal lipidomic remodeling and systemic metabolic improvement [0.03%]
达格列净可诱导肾脏脂质组结构重塑和改善全身代谢状况
Anni Li,Yuxuan Ye,Jinlin Tang et al.
Anni Li et al.
Background: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease worldwide. Sodium-glucose cotransporter-2 inhibitors (SGLT2is), such as dapagliflozin, have demonstrated renoprotective effects in the tr...