CD13 identifies S100A4+ immunosuppressive monocytes and predicts temozolomide benefit in glioblastoma [0.03%]
CD13鉴定S100A4阳性免疫抑制单核细胞并预测胶质母细胞瘤替莫唑胺治疗效益
Dong Yu,Ruiyao Hu,Qing Zhu et al.
Dong Yu et al.
Background: Glioblastoma (GBM) is an immunologically "cold" tumor in which S100A4-driven immunosuppressive myeloid cells promote progression and resistance. However, the specific immune subpopulation that intrinsically ex...
ALDH18A1 silencing inhibits lung adenocarcinoma progression through mitochondrial dysfunction and PPAR signaling pathway activation [0.03%]
沉默ALDH18A1通过抑制线粒体功能和激活PPAR信号通路来抑制肺腺癌进展
Taixu Sun,Jianming Deng,Menglin Yang et al.
Taixu Sun et al.
Background: Lung adenocarcinoma (LUAD) remains a prevalent malignant tumor characterized by a dismal prognosis. This study aimed to reveal potential mitochondria-related biomarkers and explore possible mechanisms. ...
Contactin-2 mitigates heart failure and cardiac remodeling via regulation of NUPR1 and ferroptosis [0.03%]
contactin-2通过调节NUPR1和铁死亡来缓解心力衰竭和心脏重塑
Yu-Dong Fei,Zhi-Xing Wei,Tai-Zhong Chen et al.
Yu-Dong Fei et al.
Background: The roles of Contactin-2 (CNTN2) and ferroptosis in heart failure and cardiac remodeling remain incompletely understood. Results: ...
LINC00324 induces nucleus pulposus cell apoptosis in intervertebral disc degeneration via miR-143-3p targeted TRAIL/DR4/DR5 axis [0.03%]
LINC00324通过miR-143-3p靶向TRAIL/DR4/DR5轴诱导椎间盘退变中髓核细胞凋亡
Jialin Zhang,Min Zhao,Zewei Shan et al.
Jialin Zhang et al.
Background: Intervertebral disc degeneration (IDD) serves as a predominant pathogenic driver of spinal degenerative diseases and low back pain. Long non-coding RNAs (lncRNAs) have emerged as important regulators involved ...
Epicatechin suppresses cancer stem-like cell phenotype and radioresistance in non-small cell lung cancer via targeting CXCL8 [0.03%]
表小扁桃素通过靶向CXCL8抑制非小细胞肺癌的癌症干细胞样表型和放射耐药性
Tianqian Li,Hongmei Han,Meiyan Liu et al.
Tianqian Li et al.
Background: Radiotherapy remains a cornerstone for non‑small cell lung cancer (NSCLC). However, its efficacy is frequently limited by radioresistance, a phenomenon closely associated with cancer stem-like cells (CSCs). A...
MLKL confers ferroptosis resistance in colorectal cancer cells via impaired ESCRT-III-mediated membrane repair [0.03%]
MLKL通过损害ESCRT-III介导的膜修复使结直肠癌细胞获得铁死亡抵抗性
Sasiprapa Sonkaew,Nattaya Duangthim,Chutikarn Butkinaree et al.
Sasiprapa Sonkaew et al.
Background: Ferroptosis resistance is a major challenge in cancer therapy, contributing to poor prognosis and unsatisfactory treatment outcomes. Thus, identifying key regulators of ferroptosis is essential for developing ...
Single-cell RNA sequencing reveals lipid metabolism disorders in the retina in spontaneous high myopia [0.03%]
单细胞RNA测序揭示自发性高度近视视网膜脂质代谢障碍
Bo Bao,Jinpeng Liu,Yunxiao Xie et al.
Bo Bao et al.
Background: Myopia is one of the most common eye diseases affecting children and adolescents, with its etiology often attributed to a combination of genetic and environmental factors. This study utilized single-cell RNA s...
Running exercise alleviates chronic heart failure by promoting cardiomyocyte autophagic flux through the NEAT1-QKI affecting Beclin1/LC3B mRNA stability [0.03%]
跑步运动通过NEAT1-QKI调控Beclin1/LC3B mRNA稳定性促进心肌细胞自噬流来缓解慢性心力衰竭
Ying Zhang,Rui Song,Lei Zhuang et al.
Ying Zhang et al.
As the end-stage manifestation of cardiovascular diseases (CVDs), chronic heart failure (CHF) is associated with high morbidity and mortality. Our previous study showed that Running exercise could improve CHF by inducing autophagy, but the ...
The PTHR1/PKA/CREB1 axis promotes osteosarcoma progression by activating the PVT1/miR-590-3p/AXIN2 ceRNA network to induce epithelial-mesenchymal transition [0.03%]
PTH受体1/蛋白激酶A/细胞周期蛋白反应元件结合蛋白1轴通过激活PVT1/miR-590-3p/AXIN2 ceRNA网络诱导上皮间质转化从而促进骨肉瘤的进展
Jiaming Zhang,Weishang Li,Fei Liu et al.
Jiaming Zhang et al.
Background: Osteosarcoma (OS) remains a clinically challenging primary bone tumor because of its strong metastatic potential and unsatisfactory outcomes in advanced cases. Parathyroid hormone receptor 1 (PTHR1), a recepto...
Identification and prognostic analysis of genes related to CTNNB1 mutations in hepatocellular carcinoma [0.03%]
肝细胞癌中CTNNB1突变相关基因的识别及预后分析
Ningqi Zhu,Guo Zhang,Xiaotian Shen et al.
Ningqi Zhu et al.
Background: Mutations in CTNNB1 are recognized oncogenic drivers of hepatocellular carcinoma (HCC); however, the downstream effector molecules and their prognostic significance remain incompletely defined. In this study, ...