Gper1 inhibition exacerbates traumatic brain injury-induced neurological impairments in mice [0.03%]
Gper1抑制加重小鼠创伤性脑损伤所致神经功能缺损
Ya-Fei Xue,Ying-Xi Wu,Yun-Ze Zhang et al.
Ya-Fei Xue et al.
Background: G protein-coupled estrogen receptor 1 (Gper1) is widely expressed in the brain, while its function in traumatic brain injury (TBI) remains poorly understood. This study aims to investigate the role of Gper1 in...
FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment [0.03%]
FTO（脂肪质量和肥胖相关蛋白）缺乏加剧年龄依赖性抑郁样行为和认知障碍
Mengdie Li,Yating Yang,Tangcong Chen et al.
Mengdie Li et al.
Background: The demethylase fat mass and obesity-related associated protein (FTO) is strongly associated with depression. Aging is a risk factor for synaptic plasticity damage in the brain and leads to neurocognitive dysf...
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight [0.03%]
结肠炎诱发的小鼠脑病的肠道微生物组和代谢组变化及机制研究
Aimin Cai,Dingchao Shen,Qiushuang Xiong et al.
Aimin Cai et al.
Background: In addition to classical gastrointestinal symptoms, patients with inflammatory bowel disease (IBD) often exhibit neurological manifestations, such as mood disorders and cognitive dysfunctions, which are freque...
Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model [0.03%]
联合丰富环境和氟西丁能促进慢性不可预测应激抑郁模型小鼠前额叶髓鞘形成相关蛋白的表达
Jingyang Gu,Cong Liu,Yan Li et al.
Jingyang Gu et al.
Background: The primary protein components of white matter include myelin basic protein (MBP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). Alterations in their expression are significantly implicated in depress...
Unraveling genetic risk contributions to nonverbal status in autism spectrum disorder probands [0.03%]
自闭症谱系障碍患者非言语能力的遗传风险因素解析
Huan Liu,Shenghan Wang,Binbin Cao et al.
Huan Liu et al.
Autism spectrum disorder (ASD) presents a wide range of cognitive and language impairments. In this study, we investigated the genetic basis of non-verbal status in ASD using a comprehensive genomic approach. We identified a novel common va...
Neurodegeneration models in Parkinson's disease: cellular and molecular paths to neuron death [0.03%]
帕金森病的神经退行性疾病模型：通向神经元死亡的细胞和分子途径
Diana D Álvarez-Luquín,Rubén R González-Fernández,Martin E Torres-Velasco et al.
Diana D Álvarez-Luquín et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects dopaminergic neurons in the substantia nigra pars compacta. It is a complex disease that is strongly influenced by environmental and genetic factors. While th...
Differential neuronal functions of LNX1 and LNX2 revealed by behavioural analysis in single and double knockout mice [0.03%]
行为分析单基因及双基因敲除小鼠揭示LNX1和LNX2的神经元功能差异
Laura Cioccarelli,Joan A Lenihan,Leah G Erwin et al.
Laura Cioccarelli et al.
Background: Ligand of NUMB protein-X 1 (LNX1) and LNX2 proteins are closely related PDZ domain-containing E3 ubiquitin ligases that interact with and potentially modulate numerous synaptic and neurodevelopmentally importa...
Imaging-validated correlates and implications of the pathophysiologic mechanisms of ageing-related cerebral large artery and small vessel diseases: a systematic review and meta-analysis [0.03%]
病理生理机制的影像学验证与年龄相关的大血管及小血管脑血管病的关联和影响：系统综述和meta分析
Joseph A Ackah,Xuelong Li,Huixing Zeng et al.
Joseph A Ackah et al.
Background: Cerebral large artery and small vessel diseases are considered substrates of neurological disorders. We explored how the mechanisms of neurovascular uncoupling, dysfunctional blood-brain-barrier (BBB), comprom...
Acute high-intensity noise exposure exacerbates anxiety-like behavior via neuroinflammation and blood brain barrier disruption of hippocampus in male rats [0.03%]
急性高强度噪声暴露通过神经炎症和海马血脑屏障损伤加重雄性大鼠类似焦虑的行为反应
Yifei Song,Haoyu Zhang,Xiaoni Wang et al.
Yifei Song et al.
The health risks associated with acute noise exposure are increasing, particularly the risk of mental health. This study aims to identify the association between acute high-intensity noise exposure and anxiety behavior in male rats, and to ...
A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters [0.03%]
多酚补充和运动对抑郁和脑功能参数影响的综述
Shihong Jie,Aili Fu,Chuan Wang et al.
Shihong Jie et al.
The objective of this review study is to examine the combined antidepressant effects of exercise and polyphenol supplementation, with a focus on specific polyphenolic compounds such as crocin, curcumin, and quercetin, as well as different f...