PHLPP1 deficiency alleviates dopaminergic neurodegeneration and represses neuroinflammation in Parkinson's disease [0.03%]
PHLPP1缺陷可缓解帕金森病多巴胺能神经元变性及神经炎症
Zhilin Chen,Yuan Liu,Jinyue Zhao et al.
Zhilin Chen et al.
Background: Pleckstrin homology (PH) domain leucine-rich repeat protein phosphatases (PHLPP) has been associated with several neurodegenerative diseases, however, few studies have investigated the role of PHLPP in Parkins...
Correction: Spectral tuning and after‑effects in neural entrainment [0.03%]
Correction: 频谱调节及神经同步后效现象
Maëlan Q Menetrey,David Pascucci
Maëlan Q Menetrey
Published Erratum
Behavioral and brain functions : BBF. 2025 Sep 19;21(1):28. DOI:10.1186/s12993-025-00295-w 2025
TREK-1 and epilepsy: regulating the balance of K+ and the glutamate release in astrocyte-neuron interactions [0.03%]
TREK-1与癫痫：在星形胶质细胞-神经元相互作用中调节K+和谷氨酸的平衡
Jianing Yang,Li Li,Yanan Xu et al.
Jianing Yang et al.
The TWIK-related K+ channel (TREK-1), a member of the two-pore domain potassium(K2P) family, is characterized as a "leaky potassium channel" and is integral to the maintenance of the resting membrane potential. As the most abundant cell typ...
Behavioral variant frontotemporal dementia as a model for understanding the cognitive and cerebral determinants of verbal creativity [0.03%]
行为变异型额颞叶痴呆作为理解语言创造力的认知和脑决定因素的模型
Victor Altmayer,Marcela Ovando-Tellez,Théophile Bieth et al.
Victor Altmayer et al.
Background: Although creativity is an essential cognitive function to adapt to an ever-changing world, its neurocognitive and cerebral bases still need clarification. Current models highlight the interaction between assoc...
C18:0 GM3 ganglioside's efficacy in LPS-induced parkinsonism: neuroprotection, inflammatory inhibition and gliosis mitigation [0.03%]
GM3神经节苷脂C18:0治疗脂多糖诱导的帕金森病：神经保护、抗炎和星形胶质增生作用
Tsung-Ta Liu,Cheng-Tsung Liu,I-Hsun Li et al.
Tsung-Ta Liu et al.
Background: Parkinson's disease (PD) is an incurable neurological disorder, and current pharmacological therapies primarily address symptoms without halting disease progression. Emerging evidence highlights PD as a neuroi...
Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses [0.03%]
伏正中导水管周围灰质星形胶质细胞μ-阿片受体在调节类似焦虑反应中的作用
Yinan Du,Aozhuo Zhang,Zhiwei Li et al.
Yinan Du et al.
Background: Mu-opioid receptors (MORs) are critical regulators mediating the modulation of several behavioral reactions, including analgesia, addiction, and sedation. Recent studies have reported that MORs are closely ass...
Chronic lipopolysaccharide exposure promotes cognitive impairments by activating TRPC6-AIM2 inflammasome signaling and the regulation of ginsenoside Rg1 in Trpc6-/- mice [0.03%]
慢性脂多糖暴露通过激活TRPC6-AIM2炎性小体信号通路促进认知障碍及 Ginsenoside Rg1 的调节作用：Trpc6基因敲除小鼠模型中的研究
Yinglin Fu,Hui Zhang,Xing Zhu et al.
Yinglin Fu et al.
Background: Chronic neuroinflammation is a pivotal pathogenesis in neurodegenerative diseases (NDDs). Transient receptor potential canonical protein 6 (TRPC6) has an essential role in the maintenance of calcium homeostasi...
Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice [0.03%]
多巴胺神经元Bmal1基因敲除通过男性小鼠多巴胺信号亢进诱发注意力缺陷多动症样表型
Yichun Zhang,Xin Li,Yong Liu et al.
Yichun Zhang et al.
Background: The central circadian clock coordinates daily oscillations in physiology, metabolism and behavior. Disruptions to core circadian clock genes not only perturb sleep-wake rhythms but also contribute to psychiatr...
Impaired theta and low-gamma directed information flow in the hippocampal-prefrontal circuit underlies working memory deficits in APP/PS1 mice [0.03%]
APP/PS1小鼠海马前额皮层θ频段和低γ频段定向信息流损伤导致工作记忆缺陷
Hongrui Ai,Shengnan Zhang,Chengbo Si et al.
Hongrui Ai et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. Working memory impairment, a hallmark of early-stage AD, is hypothesized to arise from deficits in encoding processes. Given the critic...
Behavioral phenotyping identifies autism-like repetitive stereotypies in a Tsc2 haploinsufficient rat model [0.03%]
行为表型分析确定了Tsc2低剂量不足大鼠模型中的自闭症类重复刻板动作
Antonia Ramme,Mirjam Zachow,Bettina Habelt et al.
Antonia Ramme et al.
Besides deficits in social communication and interaction, repetitive behavior patterns are core manifestations of autism spectrum disorder (ASD). Phenotypes are heterogeneous and can range from simple lower-order motor stereotypies to more ...