Downregulation of p120 catenin in the mouse hippocampus contributes to the development of depression-like phenotypes [0.03%]
猫粘附分子p120在海马中的下调有助于类似抑郁表型的发展
Chen Chen,Lai-Peng Feng,Pei-Ling Shi et al.
Chen Chen et al.
Background: Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and one of the leading causes of disability worldwide. Neuroinflammation is strongly implicated in the pathophysiology of MDD, suggest...
PBM alleviates depression and anxiety like behaviors in mice: insight from local field potential [0.03%]
PBM缓解小鼠抑郁样和焦虑样行为：基于局部场电位的机制解析
Yifei Tan,Jinwei Liu,Yuanrong Qiu et al.
Yifei Tan et al.
Background: Depression involves abnormal neural oscillations. Photobiomodulation (PBM) modulates such oscillations but lacks behavioral electrophysiological mechanistic studies. We explored PBM's effects on hippocampal CA...
The effect of intracerebroventricular injection of insulin-like growth factor-1 on morphine-induced conditioned place preference extinction and reinstatement; a behavioral and biochemical experimental study [0.03%]
脑室内注射胰岛素样生长因子对吗啡复吸及消退的影响：行为学和生化学研究
Erfan Ghadirzadeh,Mobina Gheibi,Ali Siahposht-Khachaki et al.
Erfan Ghadirzadeh et al.
Background: Morphine addiction is a growing problem with severe consequences. Interestingly, Insulin-like Growth Factor-1 (IGF-1), a hormone with the ability to modulate neural pathways and exert neuroprotective and regen...
Cannabinoid type 1 receptors in the mice prefrontal cortex regulate object location memory acquisition via GABAergic neurons [0.03%]
大麻素1型受体通过GABA能神经元调节小鼠前额叶皮层物体位置记忆的获得
Tomohiro Tokutake,Jun Yokose,Yusuke Yano et al.
Tomohiro Tokutake et al.
Background: Adverse psychiatric symptoms caused by cannabis are a significant concern, and Δ9-tetrahydrocannabinol (THC) has been identified as a key contributor to these symptoms. THC binds to cannabinoid type 1 recepto...
Differential cognitive enhancer effects of acetylcholinesterase inhibitors and memantine on age-related deficits in vigilance and sustained attention: a preclinical validation study [0.03%]
胆碱酯酶抑制剂和美金刚对年龄相关警觉性和持续注意力缺陷的认知增强效果的差异：一项临床前验证研究
Zsolt Kristóf Bali,Nóra Bruszt,Kitti Göntér et al.
Zsolt Kristóf Bali et al.
Background: The psychomotor vigilance task (PVT) is a cognitive test commonly used to measure sustained attention and vigilance in humans in healthy and diseased states. Here, we aimed to utilize a recently designed rat v...
Motor expertise shapes crossmodal and modality-specific action representations in table tennis players [0.03%]
运动专长影响乒乓球运动员的跨模态及特异性行动表达式
Hong Mou,Likai Liu,Yingying Wang
Hong Mou
Multivariate neuroimaging studies have shown a functional dissociation between the temporal and frontoparietal cortices in action representation. However, it remains unclear to what extent this specificity is modulated by motor experience. ...
Disruption of circadian rhythms and behavior in Drosophila melanogaster induced by Epstein-Barr virus: insights into viral infections and host physiology [0.03%]
Epstein-Barr病毒诱导的果蝇昼夜节律和行为紊乱：关于病毒感染与宿主生理的见解
Georges Naim,Sabah Znait,Nour Sherri et al.
Georges Naim et al.
Epstein-Barr virus (EBV) has been extensively studied for its associations with autoimmune disorders, various cancers, and neurological diseases. Emerging evidence also links EBV to behavioral and neurophysiological disruptions, potentially...
Copper loading may affect rat neurobehaviour by impairing mitochondria-associated endoplasmic reticulum membranes in hippocampal neurons [0.03%]
铜负荷通过损害海马神经元中与线粒体相关的内质网膜影响大鼠神经行为
Zhengzhe Sun,Shan Jin,Xiang Fang et al.
Zhengzhe Sun et al.
Background: To observe the effects of copper sulfate (CuSO4)-induced copper loading on neurobehaviour, mitochondria-associated endoplasmic reticulum membranes (MAMs) and related regulatory proteins in the hippocampal CA1 ...
Representation of top-down versus bottom-up attention in the right dorsolateral prefrontal cortex and superior parietal lobule [0.03%]
右背外侧前额叶和顶叶上回对自上而下与自下而上的注意力的表征
Qiuzhu Zhang,Wenjuan Li,Tingting Zhang et al.
Qiuzhu Zhang et al.
Background: Visual selective attention can be categorized into top-down (goal-driven) and bottom-up (stimulus-driven) attention, with the fronto-parietal network serving as the primary neural substrate. However, fewer stu...
Isoacteoside alleviates LPS-induced depressive-like behaviors in mice by inhibiting neuroinflammation through regulating microglial polarization and oxidative stress [0.03%]
异鼠李素芸香糖通过调节小胶质细胞极化和氧化应激抑制神经炎症来缓解脂多糖诱导的小鼠抑郁样行为
Jiajia Bi,Hui Zhang,Jia Wei et al.
Jiajia Bi et al.
Recent studies have demonstrated a close association between neuroinflammation and depression. Isoacteoside (ISO) has recently been reported to exhibit anti-inflammatory properties. However, the effects of ISO on neuroinflammation-induced d...