Alterations in glutamatergic and GABAergic signaling in ketamine-induced neurotoxicity: mangiferin mitigates neurochemical, oxidative, and astrocytic dysregulation in the rat temporal-frontal cortex [0.03%]
芒果儿素通过调节大鼠颞额皮质谷氨酸能和GABA能信号通路紊乱缓解氯胺酮诱导的神经毒性作用
Godson Emeka Anyanwu,Victoria Onyemachi Chukwu,Nto Johnson Nto et al.
Godson Emeka Anyanwu et al.
Background: Ketamine is an antagonist of the N-Methyl-D-aspartate (NMDA) receptor with the effect of inducing aberrant excitatory-inhibitory neurotransmission and oxidative neurotoxicity, which mimic the cognitive impairm...
Ketamine enhances histone H3 (Ser10) phosphorylation via JNK signaling and multi-omics profiling of the hippocampus in a psychotic-like mouse model [0.03%]
氯胺酮通过JNK信号传导和多组学分析在小鼠海马中增强组蛋白H3（Ser10）磷酸化
Xiu-Mei Zhu,Yang Li,Wenrui Liu et al.
Xiu-Mei Zhu et al.
Ketamine, a dissociative anesthetic, induces behavioral and molecular alterations associated with psychosis-like phenotypes. However, the epigenetic mechanisms bridging its cellular effects with behavioral outcomes are poorly defined. Here,...
Ginkgo biloba extract mitigates behavioral deficits, oxidative stress, and hippocampal remodeling in a rat model of PTSD [0.03%]
银杏叶提取物可减轻PTSD模型大鼠的行为缺陷、氧化应激和海马重塑作用
Morvarid Meamar,Zeynab Mohamadi Yarijani,Houman Parsaei et al.
Morvarid Meamar et al.
Post-traumatic stress disorder (PTSD) is associated with cognitive impairments, anxiety, fear extinction deficits, and neurobiological alterations, particularly in the hippocampus. Oxidative stress, reduced brain-derived neurotrophic factor...
Rich-club organization and functional brain network metrics during facial emotional processing: a task-based fMRI study [0.03%]
基于任务的fMRI研究面部情绪处理过程中的富人俱乐部组织和功能脑网络指标
Maryam Gholam Tamimi,Mohammad Reza Daliri
Maryam Gholam Tamimi
Background: Emotion is a complex psychological phenomenon involving both arousal and valence. emotional processing (EP) refers to the ability to perceive and interpret emotional stimuli, such as facial expressions or voca...
Postpartum enhancement of spatial learning and cognitive flexibility: an IntelliCage study [0.03%]
产后空间学习和认知灵活性的增强：一项智能笼研究
Melinda Cservenák,Luca Darai,Tamara Cecília Kállai et al.
Melinda Cservenák et al.
The transition to motherhood has been shown to result in significant changes in the structure and function of the brain, with particular emphasis on the enhancement of cognitive abilities that are essential for survival. Specifically, in mu...
Developmental trajectories of prefrontal activation underlying emotional inhibitory control from adolescence to young adulthood: a functional near-infrared spectroscopy study [0.03%]
从青少年到青年的情绪抑制控制的前额叶激活发展轨迹：近红外光谱成像研究
Tingting Chen,Lei Jiang,Rou Wen et al.
Tingting Chen et al.
Background: Understanding the neural maturation of emotional inhibitory control (IC) from adolescence to young adulthood is critical but remains incompletely characterized. The present study examined age-related differenc...
Astrocyte-derived IL-17A facilitates angiogenesis following ischemia-like injury via an IL-6-dependent STAT3-VEGF signaling cascade [0.03%]
缺血样损伤后星形胶质细胞源性IL-17A通过IL-6依赖的STAT3-VEGF信号通路促进血管生成
Xiuping Chen,Yi Zhang,Tao Huang et al.
Xiuping Chen et al.
Background: Angiogenesis plays a vital role in cerebral tissue repair following ischemic stroke. Prior in vivo studies have identified astrocytic interleukin-17A (IL-17A) as a critical mediator of post-ischemic angiogenes...
A narrative review of behavioral tests across mammalian models in neuroscience [0.03%]
神经科学领域行为测试的叙事性综述——跨哺乳动物模型
Huiling Huang,Hongping Li
Huiling Huang
Mammalian models are widely employed in the research of human diseases. Behavioral tests in animals is a critical evaluative approach in scientific research, offering insights into complex disease pathophysiology and facilitating the assess...
Knockout in zebrafish suggests a role of BDNF in behavioural and cognitive plasticity [0.03%]
斑马鱼敲除实验提示脑源性神经营养因子在行为和认知可塑性中的作用
Eleonora Rovegno,Elia Gatto,Elena Frigato et al.
Eleonora Rovegno et al.
An adaptive mechanism observed in virtually all living animals is the phenotypic plasticity, a phenomenon by which different phenotypes can develop from the same genotype depending on the environment experienced. Phenotypic plasticity can i...
Ventromedial hypothalamus IL-6 signaling mediates the excessive aggressive behavior induced by late-gestational sleep deprivation in male mice [0.03%]
妊娠晚期睡眠剥夺诱导的小鼠攻击行为增加与VMH中的IL-6信号通路有关
Fei Zhou,Xi Yu,Miao Gong et al.
Fei Zhou et al.
Background: Aggressive behavior is an evolutionarily conserved trait that supports resource acquisition and survival; however, excessive or dysregulated aggression is closely associated with neuropsychiatric disorders and...