Ahmad Syibli Othman,Catherin Marin-Mogollon,Ahmed M Salman et al.
Ahmad Syibli Othman et al.
Transgenic malaria parasites expressing foreign genes, for example fluorescent and luminescent proteins, are used extensively to interrogate parasite biology and host-parasite interactions associated with malaria pathology. Increasingly tra...
Passive and active immunization against respiratory syncytial virus for the young and old [0.03%]
针对儿童和老人的呼吸道合胞病毒被动及主动免疫法
Tonya Villafana,Judith Falloon,M Pamela Griffin et al.
Tonya Villafana et al.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants worldwide and also causes significant disease in the elderly. Despite 60 years of RSV research and vaccine development, there is only on...
Anthony L Cunningham,Thomas Heineman
Anthony L Cunningham
Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent va...
A trivalent, inactivated influenza vaccine (Vaxigrip®): summary of almost 50 years of experience and more than 1.8 billion doses distributed in over 120 countries [0.03%]
三价灭活流感疫苗（Vaxigrip®）：近五十年使用经验的总结及面向全球120多个国家的18亿剂次的推广分布
Margaret Haugh,Viviane Gresset-Bourgeois,Bérengère Macabeo et al.
Margaret Haugh et al.
Vaxigrip, a trivalent split-virion, inactivated vaccine available since 1968 has been in use longer than any other influenza vaccine. It is the most widely-used influenza vaccine, with more than 1.8 billion doses distributed in more than 12...
Sergio Rosales-Mendoza,Jorge A Salazar-González
Sergio Rosales-Mendoza
An important trend in vaccinology is the development of oral vaccines based on genetically modified plants. Areas covered: Several studies have suggested that dietary microRNAs from plants and other organisms are bioavailable upon oral inge...
Regulating vaccines at the FDA: development and licensure of Zika vaccines [0.03%]
FDA疫苗监管：开发和许可寨卡病毒疫苗
Marion F Gruber,Philip R Krause
Marion F Gruber
MTBVAC from discovery to clinical trials in tuberculosis-endemic countries [0.03%]
结核病流行国家的新型结核病亚单位疫苗MTBVAC的研发和临床试验之路
Dessislava Marinova,Jesus Gonzalo-Asensio,Nacho Aguilo et al.
Dessislava Marinova et al.
BCG remains the only vaccine against tuberculosis (TB) in use today and despite its impressive global coverage, the nature of BCG protection against the pulmonary forms of TB remains subject to ongoing debate. Because of the limitations of ...
Poliovirus vaccination during the endgame: insights from integrated modeling [0.03%]
终末期脊髓灰质炎病毒疫苗接种的模型分析给出的启示
Radboud J Duintjer Tebbens,Kimberly M Thompson
Radboud J Duintjer Tebbens
Managing the polio endgame requires access to sufficient quantities of poliovirus vaccines. After oral poliovirus vaccine (OPV) cessation, outbreaks may occur that require outbreak response using monovalent OPV (mOPV) and/or inactivated pol...
Pre-clinical and clinical development of the first placental malaria vaccine [0.03%]
首个胎盘疟疾疫苗的临床前和临床开发
Caroline Pehrson,Ali Salanti,Thor G Theander et al.
Caroline Pehrson et al.
Malaria during pregnancy is a massive health problem in endemic areas. Placental malaria infections caused by Plasmodium falciparum are responsible for up to one million babies being born with a low birth weight every year. Significant effo...
Richard H Scheuermann,Robert S Sinkovits,Theodore Schenkelberg et al.
Richard H Scheuermann et al.
Biomedical research has become a data intensive science in which high throughput experimentation is producing comprehensive data about biological systems at an ever-increasing pace. The Human Vaccines Project is a new public-private partner...