Livio Garattini,Alessandro Curto,Anna Padula
Livio Garattini
The prevalence of child-specific utilities in NICE appraisals for paediatric indications: rise of the economic orphans? [0.03%]
英国NICE儿童适应症卫生技术评估中以儿童为主体效用值的流行情况：经济孤儿现象的兴起？
Stephen Maxwell Montgomery,Jeanette Kusel
Stephen Maxwell Montgomery
Children are not mini-adults, and thus require studies to be conducted in the population of interest to inform decisions about their care. The paucity of such studies for clinical efficacy lead them to be termed 'therapeutic orphans'. Follo...
An innovative outcome-based care and procurement model of hemophilia management [0.03%]
一种创新的以结果为导向的出血管理照护与采购模式
Alessandro Gringeri,Jennifer Doralt,Leonard A Valentino et al.
Alessandro Gringeri et al.
Hemophilia is a rare bleeding disorder associated with spontaneous and post-traumatic bleeding. Each hemophilia patient requires a personalized approach to episodic or prophylactic treatment, but self-management can be challenging for patie...
Non-adherence with bisphosphonates among patients with osteoporosis: impact on fracture risk and healthcare cost [0.03%]
骨质疏松症患者的双磷酸盐非依从性对其骨折风险和医疗保健费用的影响
Gabriel Chodick,Sarah Sharman Moser,Inbal Goldshtein
Gabriel Chodick
Osteoporosis-related fractures at the spine and hip have a substantial impact on mortality, morbidity, and quality of life in older adults worldwide. Adherence to bisphosphonates is essential for effective treatment and fracture prevention....
Variations in costs and use of provincially-funded testosterone replacement therapy across Canada: a population-based study [0.03%]
一项基于人群的跨加拿大研究：省级资助的睾酮替代疗法的成本和使用情况的差异
Mina Tadrous,Diana Martins,Kathy Lee et al.
Mina Tadrous et al.
Introduction: Provincial drug-program policies for the reimbursement of testosterone replacement therapy (TRT) vary across Canada, which may result in marked regional variability in use. ...
Review and comparison of methodologies for indirect comparison of clinical trial results: an illustration with ranibizumab and aflibercept [0.03%]
间接对比临床试验结果的方法学回顾及比较——以兰尼单抗和阿菲莫单抗为例
Stephane A Regnier,Jonathan Alsop,Jonathan Wright et al.
Stephane A Regnier et al.
Aim: To review and compare methods for indirect comparison of aflibercept and ranibizumab in patients with diabetic macular edema. Methods: ...
Palliative care outcome measures in COPD patients: a conceptual review [0.03%]
慢性阻塞性肺疾病终末期患者预后评估指标体系研究进展的概念性综述
Sabina Antonela Antoniu,Lucian Vasile Boiculese
Sabina Antonela Antoniu
In chronic obstructive pulmonary disease (COPD), palliative care is appropriate in very advanced stages based on recognition of its need when conventional therapy is no longer able to control symptoms, disease morbidity, or to improve/maint...
Advantages and disadvantages of discrete-event simulation for health economic analyses [0.03%]
离散事件模拟在卫生经济分析中的利弊
J Jaime Caro,Jörgen Möller
J Jaime Caro
Addressing challenges for sustainable healthcare in Central and Eastern Europe [0.03%]
中欧和东欧可持续卫生系统的挑战及应对措施
Brian Godman,Tanja Novakovic,Danka Tesic et al.
Brian Godman et al.
All European countries face increasing challenges in the provision of equitable and comprehensive healthcare for their citizens in view of a number of factors. These include changing demographics and the continual launch of new premium pric...
Amos Massele,Celda Tiroyakgosi,Matshediso Matome et al.
Amos Massele et al.
There is a need to improve the rational use of antibiotics across continents including Africa. This has resulted in initiatives in Botswana including treatment guidelines and the instigation of Antibiotic Stewardship Programs (ASPs). The ne...