Michel Farnier
Michel Farnier
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in lipoprotein metabolism, mainly by modulating LDL receptor activity. Alirocumab is a fully human IgG1 monoclonal antibody that binds PCSK9, increases the number...
Giovanni La Canna,Paolo Denti,Nicola Buzzatti et al.
Giovanni La Canna et al.
In recent years, various percutaneous techniques have been introduced for the treatment of mitral regurgitation (MR), including direct leaflet repair, annuloplasty and left ventricular remodeling. Percutaneous mitral repair targets both pri...
Mahsun Yuerek,Joseph W Rossano,Christopher E Mascio et al.
Mahsun Yuerek et al.
Low cardiac output syndrome (LCOS) is a well-described entity occurring in 25-65% of pediatric patients undergoing open-heart surgery. With judicious intensive care management of LCOS, most patients have an uncomplicated postoperative cours...
A Bossu,M A G van der Heyden,T P de Boer et al.
A Bossu et al.
Drug-induced Torsade de Pointes arrhythmia is a life-threatening adverse effect feared by pharmaceutical companies. For the last decade, the cardiac safety guidelines have imposed human ether-a-go-go-related gene channel blockade and prolon...
The SAMe-TT2R2 score and decision-making between a vitamin K antagonist or a non-vitamin K antagonist oral anticoagulant in patients with atrial fibrillation [0.03%]
SAMe-TT2R2评分与心房颤动患者维生素K拮抗剂或非维生素K拮抗剂口服抗凝药的选择
María Asunción Esteve-Pastor,Vanessa Roldán,Mariano Valdés et al.
María Asunción Esteve-Pastor et al.
Oral anticoagulation therapy is essential in patients with atrial fibrillation and clinicians need guidance on decision-making between the vitamin K antagonists (VKA), e.g. warfarin, or non-vitamin K antagonist oral anticoagulants. Observat...
Association between various anthropometric measures of obesity and markers of subclinical atherosclerosis [0.03%]
肥胖的各种体质测量指标与亚临床动脉粥样硬化标志物之间的关系
Naga V A Kommuri,Sandip K Zalawadiya,Vikas Veeranna et al.
Naga V A Kommuri et al.
Central obesity is a known cardiovascular risk factor and measures of visceral obesity are known to predict atherosclerosis. This study sought to explore the association between various anthropometric measures and markers of subclinical ath...
Udaya S Tantry,Fang Liu,Gailing Chen et al.
Udaya S Tantry et al.
Dual antiplatelet therapy with aspirin, a platelet cyclooxygenase-1 inhibitor and P2Y12 receptor blockers, remains the major drug strategy to prevent ischemic event occurrence in patients with acute coronary syndromes and in patients underg...
How to approach the great mimic? Improving techniques for the diagnosis of myocarditis [0.03%]
如何应对模仿大师？提高心肌炎诊断技术的方法
Sophie Mavrogeni,George Markousis-Mavrogenis,Genovefa Kolovou
Sophie Mavrogeni
Myocarditis is characterized by inflammation of the myocardium, assessed by histological, immunological and immunohistochemical criteria, due to exogenous or endogenous causes. Abnormal QRS, increased troponin T and left ventricular regiona...
The use of transthoracic echocardiography for the assessment of left ventricular systolic and diastolic function in patients with suspected or ascertained chronic heart failure [0.03%]
经胸超声心动图评估疑似或确诊慢性心力衰竭患者左室收缩及舒张功能的应用
Roberta Esposito,Regina Sorrentino,Maurizio Galderisi
Roberta Esposito
Several indices are available to assess left ventricular (LV) function. Although ejection fraction (EF) is widely used, it has many limitations. An assessment of LV longitudinal function should be therefore provided as it precedes the impai...
Dual-energy computed tomography for detection of coronary artery disease [0.03%]
双源CT冠状动脉成像检查冠心病的临床应用价值分析
Ibrahim Danad,Bríain Ó Hartaigh,James K Min
Ibrahim Danad
Recent technological advances in computed tomography (CT) technology have fulfilled the prerequisites for the cardiac application of dual-energy CT (DECT) imaging. By exploiting the unique characteristics of materials when exposed to two di...