Management of relapsed ovarian cancer in routine clinical practice: a case study [0.03%]
复发卵巢癌的临床管理：个案研究
Isabelle Ray-Coquard
Isabelle Ray-Coquard
Objective: In patients with recurrent ovarian cancer, there are certain situations where further surgery and/or next-line platinum-based chemotherapy is not feasible or is not the best option. Multidisciplinary teams have...
Recurrent ovarian cancer 8 months after induction and bevacizumab consolidation: rationale for using trabectedin + pegylated liposomal doxorubicin in second line [0.03%]
诱导化疗和贝伐单抗维持治疗后8个月复发的卵巢癌二线使用трабectedin联合pegylated liposomal doxorubicin的依据
Nicoletta Colombo
Nicoletta Colombo
Objectives: Ovarian cancer patients with relapse 6-12 months after last platinum treatment, who have received bevacizumab consolidation and are not BRCA mutant, represent a considerable therapeutic challenge. ...
Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives [0.03%]
ω-3多不饱和脂肪酸在预防消化系统癌症中的作用：现状与未来展望
Ho-Jae Lee,Young-Min Han,Jeong Min An et al.
Ho-Jae Lee et al.
Although inflammation is defensive and healing process that maintains organ homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids (PUFAs), especially n-6 PUFAs abundant in Western diet, are precursors of pro...
Andrea Spallanzani,Giulia Orsi,Kalliopi Andrikou et al.
Andrea Spallanzani et al.
Since 2007 Sorafenib has represented the only approved drug for first-line treatment of advanced hepatocellular carcinoma (HCC). Lenvatinib, an orally active inhibitor of multiple receptor tyrosine kinases (VEGFR 1-3, FGFR 1-4, PDGFRa, RET ...
Preserving quality of life as a key treatment goal in advanced soft tissue sarcomas [0.03%]
在晚期软组织肉瘤的治疗中保持生活质量为主要目标
Robin L Jones,Axel Le Cesne,Tony Ibrahim et al.
Robin L Jones et al.
Health-related quality of life (HRQoL) is a patient-reported outcome that addresses patients' perceptions of symptoms across physical, emotional, cognitive and social domains. As HRQoL is currently rarely measured outside clinical trials in...
Dabrafenib and trametinib for the treatment of non-small cell lung cancer [0.03%]
达拉菲尼和曲马替尼用于治疗非小细胞肺癌
Ronan J Kelly
Ronan J Kelly
BRAFV600E mutations occur in 1-2% of lung adenocarcinomas and act as oncogenic drivers via the mitogen-activated protein kinase (MAPK) pathway. These mutations are mutually exclusive from the more common, epidermal growth factor receptor mu...
Paweł Krawczyk,Renata Duchnowska,Marcin Nicoś et al.
Paweł Krawczyk et al.
There are no effective central nervous system (CNS) metastases prevention methods in lung cancer patients. Prophylactic cranial irradiation has a limited effectiveness and relatively high toxicity. Systemic chemotherapy is not relevant in r...
Increased cancer incidence in Holocaust survivors and the implications for survivors of other extreme events [0.03%]
大屠杀幸存者的癌症发病率升高及其对其他极端事件幸存者的意义
Lital Keinan-Boker
Lital Keinan-Boker
Rosaria Condorelli,Ines Vaz-Luis
Rosaria Condorelli
Recent improvements in the survival of hormone-responsive breast cancer are strongly associated with therapeutic advances, particularly with the uptake of adjuvant endocrine therapy. Nevertheless, endocrine therapy is also linked with adver...
Laparoscopic surgery for gastric cancer: where are we now and where are we going? [0.03%]
胃癌腹腔镜手术的现状与未来方向在哪里？
Lei Huang,Tuan-Jie Li
Lei Huang
Minimally-invasive surgery is gaining increasing popularity for the management of gastric cancer (GC). Areas covered: The authors hereby comprehensively and systematically reviewed the randomized and/or prospective evidence on laparoscopic ...