Steps toward the clinical application of endometrial and menstrual fluid mesenchymal stem cells for the treatment of gynecological disorders [0.03%]
子宫内膜和月经干细胞向妇科疾病临床应用的转化研究步骤
Alexander Sadiasa,Jerome A Werkmeister,Shanti Gurung et al.
Alexander Sadiasa et al.
Introduction: The human endometrium is a highly regenerative tissue that contains mesenchymal stem/stromal cells (MSCs). These MSCs are sourced via office-based biopsies and menstrual fluid providing a less invasive and r...
Literature review and expert opinion on diagnosis and current management of generalized pustular psoriasis [0.03%]
关于泛发性脓疱型银屑病诊断和现有治疗方案的文献回顾与专家意见
Angelo Valerio Marzano,Maria Concetta Fargnoli,Paolo Gisondi et al.
Angelo Valerio Marzano et al.
Introduction: Generalized pustular psoriasis (GPP) is a rare, chronic, systemic, autoinflammatory disease characterized by the eruption of sterile pustules, often accompanied by more general symptoms, such as fever, fatig...
An evaluation of linvoseltamab for treatment of relapsed/refractory multiple myeloma [0.03%]
林沃色马布治疗复发/难治多发性骨髓瘤的疗效评价
Zachary M Avigan,Mohammad A Rattu,Joshua Richter
Zachary M Avigan
Introduction: Bispecific antibody therapies, primarily targeting B-cell maturation antigen (BCMA), have shown remarkable outcomes in the treatment of heavily pretreated patients with multiple myeloma (MM). However, there ...
Successes and failures: the latest advances in the clinical development of amyloid-β-targeting monoclonal antibodies for treating Alzheimer's disease [0.03%]
成功与失败：针对阿尔茨海默病治疗的抗淀粉样蛋白抗体临床开发最新进展
Francesco Panza,Vittorio Dibello,Rodolfo Sardone et al.
Francesco Panza et al.
Introduction: The amyloid cascade hypothesis postulated that the accumulation of amyloid-β (Aβ) was the first step of the Alzheimer's disease (AD) pathological process. Effective reduction of Aβ plaque load by numerous...
Navigating the landscape of immune checkpoint inhibitors and novel immunotherapies in melanoma: long-term outcomes, progress, and challenges [0.03%]
免疫检查点抑制剂和新型免疫治疗在黑色素瘤中的应用：长期疗效、进展与挑战
Sowmya Cheruvu,David McMahon,James Larkin
Sowmya Cheruvu
Introduction: Melanoma has become the poster child for transformative outcomes in advanced malignancy from the use of immunotherapy over the last 10-15 years with median survival improving from ~ 1 to > 5 years. With the ...
Maram Ea Abdalla Elsayed,Jasmina Cehajic Kapetanovic,Robert E MacLaren
Maram Ea Abdalla Elsayed
Introduction Choroideremia is a rare disease with a significant disease burden. Gene-supplementation methods for choroideremia gene therapy have been the most successful form of gene therapy thus far. Areas covered The aim of the current re...
How should we approach salvage therapy in advanced renal cell carcinoma after first-line immunotherapy combinations? [0.03%]
一线免疫治疗联合治疗后的晚期肾细胞癌患者的挽救治疗应如何选择？
Paul Sackstein,Michael B Atkins
Paul Sackstein
An evaluation of mepolizumab as an add-on maintenance treatment for severe eosinophilic asthma [0.03%]
关于美普兹单抗作为重度嗜酸性粒细胞性哮喘附加维持治疗的评估研究
Zheng Zhu,Xiaoying Chen,Yiting Luo et al.
Zheng Zhu et al.
Introduction: Clinical experience with anti-interleukin (IL)-5 biologic therapies for severe asthma has been increasing, alongside deeper and broader research focusing on the role of IL-5 and the IL-5 targeted mepolizumab...
Treating episodic migraine with precision: the evolving landscape of targeted therapies driven by insights in disease biology [0.03%]
精准治疗发作性偏头痛：由疾病生物学洞察驱动的靶向疗法的发展格局
Robert Fleischmann,Sebastian Strauß,Uwe Reuter
Robert Fleischmann
Introduction: Migraine is a disabling neurological disorder with a complex neurobiology. It appears as a cyclic disorder of sensory processing, affecting multiple systems beyond nociception. Overlapping mechanisms, includ...
Biosimilars in pediatric rheumatology: innovations, challenges, and opportunities [0.03%]
儿科风湿病学中的生物类似药：创新、挑战与机遇
Ali Öksel,Hafize Emine Sönmez,Nihal Şahin
Ali Öksel
Introduction: Biosimilars are biologic medications designed to closely replicate the properties of previously approved biologic disease-modifying anti-rheumatic drugs (bDMARDs). They offer a cost-effective alternative onc...