Belimumab patient profile in Spain: evolution during the last decade and future directions [0.03%]
西班牙belimumab患者的概况：过去十年的发展和未来方向
Tarek Carlos Salman-Monte,María José Cuadrado,María Galindo et al.
Tarek Carlos Salman-Monte et al.
Introduction: Belimumab (BEL), an anti B-lymphocyte stimulator monoclonal antibody, is the only approved biological therapy for systemic lupus erythematosus (SLE) and lupus nephritis (LN). ...
A plain language summary of the pooled safety results of adalimumab-adbm from the VOLTAIRE clinical trials in people with rheumatoid arthritis, Crohn's disease, and chronic plaque psoriasis [0.03%]
来自VOLTAIRE临床试验的adalimumab-adbm在类风湿关节炎、克罗恩病和慢性斑块状牛皮癣患者中汇总的安全性结果的白话总结
Stanley Cohen,Shaun Bender,Amy Shaberman et al.
Stanley Cohen et al.
A review of antibody-based immunotherapy clinical trials for adult acute myeloid leukemia (AML): monoclonal antibodies (mAbs) and beyond [0.03%]
基于抗体的成人急性髓系白血病（AML）免疫治疗临床试验回顾：单克隆抗体(mAb)及其它方法
Kaitlyn C Dykes,Edward D Ball
Kaitlyn C Dykes
Introduction: Antibody-based immunotherapies are a class of therapeutics under active investigation in clinical trials for the treatment of acute myeloid leukemia (AML). Our review provides a comprehensive examination of ...
State of the art of the molecular hyperselection to guide treatment with anti-EGFR antibodies in RAS WT mCRC: implications for clinical practice and future perspectives [0.03%]
分子超选择在RAS野生型转移性结直肠癌中指导抗EGFR抗体治疗的最新进展：对临床实践和未来展望的影响
Pilar García-Alfonso,Manuel Valladares-Ayerbes,Andrés J Muñoz Martín et al.
Pilar García-Alfonso et al.
Introduction: Adding monoclonal antibodies to chemotherapy drastically changed the landscape of advanced colorectal cancer. The prediction of benefit from anti-EGFR therapies is mainly based on the absence of mutations in...
Chasing optimal first-in-human (FIH) starting dose for biotherapeutics in oncology [0.03%]
癌症生物药物首次人体(FIH)起始剂量优化的探索之路
Céline Amara
Céline Amara
Cristina Martin,Laurent Servais
Cristina Martin
Introduction: X-linked myotubular myopathy (XLMTM) is a life-threatening congenital disorder characterized by severe respiratory and motor impairment. This disease presents significant therapeutic challenges, with various...
Optimizing biosimilar development: current approaches to demonstrating pharmacokinetic and analytical similarity and a proposal for a single reference approach [0.03%]
生物类似物开发的优化：展示药代动力学和分析相似性的现行方法及采取单一参照方法的提议
David Murray,Peter Kiely
David Murray
Objectives: Many biosimilars have been approved in both the United States of America (U.S.A.) and European Union (EU). We aim to highlight how regulatory challenges and divergent requirements between both agencies exist. ...
Psoriasis and cancer: the role of inflammation, immunosuppression, and cancer treatment [0.03%]
银屑病与癌症：炎症、免疫抑制及癌症治疗的作用
Manfredo Bruni,Fabio Lobefaro,Cristina Pellegrini et al.
Manfredo Bruni et al.
Introduction: The relationship between psoriasis, immunomodulatory therapies, and the risk of malignancies is complex and still debated. The scarcity of evidence in this field makes clinicians hesitate to prescribe biolog...
Corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based therapies for knee osteoarthritis - literature trends are shifting in the injectable treatments' evidence: a systematic review and expert opinion [0.03%]
膝骨关节炎的皮质类固醇，玻璃酸，富血小板血浆和基于细胞的治疗-文献趋势正在改变可注射治疗方法的证据：系统评价和专家意见
Alessandro Bensa,Luca Bianco Prevot,Giacomo Moraca et al.
Alessandro Bensa et al.
Introduction: The aim of this systematic review was to quantify the data available on corticosteroids (CS), hyaluronic acid, (HA), platelet-rich plasma (PRP), and cell-based therapies for knee osteoarthritis (OA) treatmen...
Drawing on collective action theory to foster sustainable biosimilar markets - insights from co-creation workshops with UK and Belgian stakeholders [0.03%]
借鉴集体行动理论促进可持续的生物类似药市场--来自英国和比利时利益相关者共同创作研讨会的观点
Teresa Barcina Lacosta,Arnold G Vulto,Florian Turk et al.
Teresa Barcina Lacosta et al.
Background: Research has signaled the need for reformed biosimilar policy frameworks that adopt a behavioral approach, are informed by consensus-generating strategies and thus better align with the requirements of local h...