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期刊名:Expert opinion on therapeutic patents

缩写:EXPERT OPIN THER PAT

ISSN:1354-3776

e-ISSN:1744-7674

IF/分区:4.6/Q1

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共收录本刊相关文章索引1521
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Jean Dessolin Jean Dessolin
A new series of oxazin amides have been synthesized from isoxazoles using a reaction to increase the heterocyclic ring size and were evaluated as BACE1 inhibitors. The innovative compounds were able to diminish amyloid-β peptide concentrat...
Alberto Leoni,Alessandra Locatelli,Rita Morigi et al. Alberto Leoni et al.
Introduction: Thiazole is a well-known five-membered heterocyclic compound. Various methods have been worked out for its synthesis. In the last few decades, a lot of work has been done on thiazole ring in order to find ne...
Matthieu Collin,Frederic Niemann,Frédéric Jaisser Matthieu Collin
Introduction: Considered for years as a 'renal hormone' leading to the control of renal excretion of minerals (explaining the term 'mineralocorticoid' used to describe this hormone), aldosterone is now recognized as a key...
Lisa L Mueller,Silvia Moreira Taketsuma Costa Lisa L Mueller
Pharmaceutical manufacturers who seek new markets for expansion are particularly attracted to Brazil given its potential for growth and the expectation that it will be the fifth largest drug market by 2015. Given the significance of Brazil ...
Peter Norman Peter Norman
A series of pyrrolo[2,3-d]pyrimidine derivatives have previously been claimed as Janus kinase (JAK) 1 selective inhibitors. Introduction of a 4-aryl substituent onto this bicyclic scaffold modulates the JAK selectivity profile, thus providi...
Philip Webber Philip Webber
For over 20 years, the US Patent & Trademark Office (USPTO) has been granting patents to DNA sequences. But on 13 June 2013, the US Supreme Court decided that genomic DNA sequences are unpatentable because they are products of nature. This ...
Dorota Łażewska,Katarzyna Kieć-Kononowicz Dorota Łażewska
Introduction: Histamine H3 receptor (H3R) is involved in the central and peripheral regulation of levels of histamine and other neurotransmitters (e.g., acetylcholine, noradrenaline, dopamine or serotonin). H3R antagonist...
Gubbi M Arunesh,Ekambaram Shanthi,Mudeenahally H Krishna et al. Gubbi M Arunesh et al.
Introduction: The proviral insertion in murine (PIM) lymphoma proteins for which three isoforms, PIM1, PIM2 and PIM3 have been identified, belonging to the family of serine/threonine kinases has emerged recently as an imp...
Akul Y Mehta,Yingzi Jin,Umesh R Desai Akul Y Mehta
Introduction: Thromboembolic incidences have increased nearly 33% in the past decade and directly affect nearly 0.5% of the population. Heparin, warfarin and current direct thrombin inhibitors (DTIs), the primary anticoag...
Somnath Halder,Sanjay Kumar,Rajiv Sharma Somnath Halder
Introduction: Type 2 diabetes (T2D) is a complex metabolic disorder characterized by persistent hyperglycemia and a wide range of underlying metabolic defects. The prevalence and incidence of T2D are expected to dramatica...