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期刊名:Expert opinion on therapeutic patents

缩写:EXPERT OPIN THER PAT

ISSN:1354-3776

e-ISSN:1744-7674

IF/分区:4.6/Q1

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共收录本刊相关文章索引1521
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Peter Norman Peter Norman
Three patent applications, from two different companies, claim structurally novel Tyk2 inhibitors and their uses for the treatment of autoimmune diseases. In EP-2634185 Sareum claims 5-anilino-2-(2-halophenyl)-oxazole-4-carboxamide derivati...
Michael Risch Michael Risch
The patent troll debate has reached a fevered pitch in the USA. This editorial seeks to frame the debate by pointing out the lack of clarity in defining patent trolls and their allegedly harmful actions. It then frames the debate by asking ...
Yi-Min Liu,Hsiao-Ling Chen,Hsueh-Yun Lee et al. Yi-Min Liu et al.
Introduction: Microtubules play an important role in several cellular processes, particularly in the formation of the mitotic spindle during the process of mitosis. These highly dynamic mitotic-spindle microtubules have b...
Liming Shao,Wei Li,Qiong Xie et al. Liming Shao et al.
Introduction: The dysfunctions of three very important monoamine neurotransmitters, serotonin (5-HT), norepinephrine (NE) and dopamine (DA), are associated with some of important CNS diseases such as depression; developin...
Yangbo Feng,Philip V LoGrasso Yangbo Feng
Introduction: The Rho kinase/ROCK is critical in vital signal transduction pathways central to many essential cellular activities. Since ROCK possess multiple substrates, modulation of ROCK activity is useful for treatmen...
Peter Norman Peter Norman
This application claims two crystalline forms and inhaled formulations of a the selective phosphatidylinositol 3-kinase-δ inhibitor (PI3Kδ) inhibitor 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorob...
Kongkai Zhu,Xiangqian Kong,Dan Zhao et al. Kongkai Zhu et al.
Introduction: The receptor tyrosine kinase c-MET displays aberrant activation in the malignant phenotype of various tumors, and thus, has drawn considerable attention as drug target for cancer therapy. Many c-MET inhibito...
Peter Norman Peter Norman
1-alkyl-3-arylaminopyrazole-4-carboxamide derivatives have previously been described as JAK2 selective inhibitors. Modification of the 1-substituent to incorporate a 2-cyanoethyl moiety modulates the selectivity for JAK kinases providing JA...
Jean-Marc Garnier,Phillip P Sharp,Christopher J Burns Jean-Marc Garnier
Introduction: The bromodomain (BRD) and extra-C terminal domain (BET) protein family consists of four members (BRD2, BRD3, BRD4 and BRDT). These "epigenetic readers" bind to acetyllysine (KAc) residues on the tails of his...
David A Powell David A Powell
Introduction: Stearoyl coenzyme-A desaturase (SCD) is a critical lipogenic enzyme that converts a range of unsaturated lipids to their corresponding monounsaturated fatty acids. Genetic and enzyme-knockdown experiments ha...