Ahmed Kamal,Shaikh Faazil,Mohammed Shaheer Malik
Ahmed Kamal
Introduction: Apoptosis is an important and extensively studied pathway of programmed cell death, which is central to different physiological processes. Varied pathological implications, not limited to cancer and neurodeg...
Roberto Gambari
Roberto Gambari
Introduction: DNA/RNA-based drugs are considered of major interest in molecular diagnosis and nonviral gene therapy. In this field, peptide nucleic acids (PNAs, DNA analogs in which the sugar-phosphate backbone is replace...
Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011 - 2013) [0.03%]
组蛋白去乙酰化酶小分子抑制剂在抗肿瘤及非肿瘤疾病的应用专利点评（2011-2013）
Sergio Valente,Antonello Mai
Sergio Valente
Introduction: Histone deacetylases (HDACs) play an important role in mediating the expression of genes involved in cancer and non-cancer diseases. Overexpression of these enzymes has been shown in several types of cancer ...
María Victoria Castelli,Estefanía Butassi,María Candida Monteiro et al.
María Victoria Castelli et al.
Introduction: Invasive fungal infections (IFI) have increased significantly over the past decades. The mortality rate of IFI is alarming, and early and accurate diagnosis is difficult. Most used antifungal drugs are not c...
Novel picolinamide-based cystic fibrosis transmembrane regulator modulators: evaluation of WO2013038373, WO2013038376, WO2013038381, WO2013038386 and WO2013038390 [0.03%]
新颖的吡啶甲酰胺类囊性纤维化跨膜转导调节剂：评估WO2013038373，WO2013038376，WO2013038381，WO2013038386和WO2013038390
Peter Norman
Peter Norman
Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, Δ508CFTR, produces a protein that is misfolded and does not ...
Evaluation of WO2013117503 and WO2013117504: the use of PI3K inhibitors to treat cough or idiopathic pulmonary fibrosis [0.03%]
WO2013117503和WO2013117504的评价：PI3K抑制剂用于治疗咳嗽或特发性肺纤维化
Peter Norman
Peter Norman
Two applications claim the use of the closely related, broad spectrum phosphatidylinositol 3-kinase inhibitors 2,4-difluoro-N-{2-(methoxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide (GSK-2126458) and 2,4-difluoro-N-{2...
Terpenes and derivatives as a new perspective for pain treatment: a patent review [0.03%]
萜类和衍生物在疼痛治疗中的新视角：专利回顾
Adriana G Guimarães,Mairim R Serafini,Lucindo J Quintans-Júnior
Adriana G Guimarães
Introduction: Terpenes are natural compounds found in several organisms belonging to the animal and plant kingdoms. They constitute the largest class of natural products with > 55,000 known compounds structurally diversif...
Evaluation of WO2013116562A, an orally active PI3Kδ inhibitor for the treatment of asthma [0.03%]
WO2013116562A口服活性PI3Kδ抑制剂治疗哮喘的评估
Peter Norman
Peter Norman
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile is claimed as a highly selective, PI3Kδ inhibitor. It is claimed to be useful in the treatment of asthma and appears intended for o...
Epidermal growth factor receptor inhibitors: a patent review (2010 - present) [0.03%]
表皮生长因子受体抑制剂专利回顾（2010-至今）
Si-Ning Li,Huan-Qiu Li
Si-Ning Li
Introduction: The signaling pathways downstream of epidermal growth factor receptor (EGFR) are central to the biology of colorectal cancer. EGFR kinase represents an attractive target for the development of novel therapie...
Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497 [0.03%]
用于tau病理学检测的氨基菲啶并噻唑类药物：WO2013090497专利分析与评价
Carlo Ballatore,Amos B Smith rd,Virginia M-Y Lee et al.
Carlo Ballatore et al.
Small-molecule ligands, amenable to positron emission tomography (PET) imaging of different types of neurodegenerative disease-associated amyloid deposits in the CNS of living patients, hold considerable promise for diagnostic purposes, as ...