Spleen tyrosine kinase inhibitors: a review of the patent literature 2010 - 2013 [0.03%]
sple tyrosine激酶抑制剂的专利文献回顾（2010-2013）
Peter Norman
Peter Norman
Introduction: The non-receptor tyrosine kinase, spleen tyrosine kinase (Syk), is primarily expressed in haematopoietic cells and appears to be particularly important in B cells. Syk is involved in signal transduction proc...
Michael P Dwyer,Younong Yu
Michael P Dwyer
Introduction: Small-molecule antagonists of CXC chemokine receptor 2 (CXCR2) have attracted a considerable amount of attention due to the key central role that this receptor plays in inflammatory conditions. Recently, sev...
Anaplastic lymphoma kinase inhibitors as anticancer therapeutics: a patent review [0.03%]
致癌药物的研发：alk抑制剂相关专利的回顾分析
Eugen F Mesaros,Gregory R Ott,Bruce D Dorsey
Eugen F Mesaros
Introduction: Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase from the insulin receptor superfamily, is implicated in the oncogenesis of numerous cancers including anaplastic large-cell lymphoma, non-small-ce...
Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218) [0.03%]
选择性及可逆性的泛素特异性蛋白酶7抑制剂：一项专利评估（专利号：WO2013030218）
Benedikt M Kessler
Benedikt M Kessler
The invention described in this review (WO2013030218) relates to compounds based on the quinazolin-4-one scaffold, their process of preparation and applications to inhibit the ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme ...
Boron-containing compounds: chemico-biological properties and expanding medicinal potential in prevention, diagnosis and therapy [0.03%]
含硼化合物的化学-生物性质及其在预防、诊断和治疗中的医学潜力拓展
Marvin A Soriano-Ursúa,Bhaskar C Das,José G Trujillo-Ferrara
Marvin A Soriano-Ursúa
Introduction: Although the medicinal use of boron-containing compounds (BCCs) had long been limited to antiseptics, in the last few decades, these compounds have been used as antibiotics or chemotherapeutic agents. In the...
Shoya Yamada,Hiroki Kakuta
Shoya Yamada
Introduction: Retinoid X receptors (RXRs) are nuclear receptors that act as ligand-dependent transcription factors. RXRs function as homodimers or as heterodimers with other nuclear receptors, such as retinoic acid recept...
Waleed M Hussein,Tzu-Yu Liu,Mariusz Skwarczynski et al.
Waleed M Hussein et al.
Introduction: Toll-like receptors (TLRs) are a crucial part of the innate immunity and present the first line of defense against pathogens. In humans, there are ten TLRs, with TLR3, 7, 8 and 9 located in intracellular ves...
Anti-IL-36R antibodies, potentially useful for the treatment of psoriasis: a patent evaluation of WO2013074569 [0.03%]
抗IL-36R抗体可能用于银屑病治疗：评估WO2013074569专利申请书
Joel Wolf,Laura Korb Ferris
Joel Wolf
The IL-36 family of cytokines and receptors seems to play a role in the pathogenesis of both pustular psoriasis, and the much more common variant, plaque-type psoriasis. Human skin biopsies from patients with psoriasis show overexpression o...
Rainer Metcalf,Latanya M Scott,Kenyon G Daniel et al.
Rainer Metcalf et al.
Introduction: Over the past 3 years, numerous patents and patent applications have been submitted and published involving compounds designed to inhibit the proteasome. Proteasome inhibition has been of great interest in c...
Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature [0.03%]
新的信号转导子和转录激活子3信号传导途径抑制剂：近期专利文献更新
Antonio Lavecchia,Carmen Di Giovanni,Carmen Cerchia
Antonio Lavecchia
Introduction: The signal transducer and activator of transcription 3 (STAT3) is a transcription factor that plays a key role in normal cell growth and is constitutively activated in about 70% of solid and hematological ca...