The use of salt-inducible kinase inhibitors to treat autoimmune and inflammatory diseases: evaluation of WO2013136070 [0.03%]
盐诱导激酶抑制剂在自身免疫病和炎症性疾病治疗中的应用:评价WO2013136070A1专利申请书
Peter Norman
Peter Norman
Novel methods for the treatment of inflammatory and autoimmune diseases comprising the administration of salt-inducible kinase inhibitors are claimed. One novel inhibitor (HG-9-91-01) and the use of 2,4-diaminopyrimidine and 2,6-diaminopyri...
Tony Taldone,Hardik J Patel,Alexander Bolaender et al.
Tony Taldone et al.
Introduction: Heat shock proteins (Hsps) are proteins with important functions in regulating disease phenotypes. Historically, Hsp90 has first received recognition as a target in cancer, with consequent efforts extending ...
Bryan Collinsworth,Sara E Crager
Bryan Collinsworth
Universities conduct biomedical research with the self-stated goal of disseminating the benefits to the global public. Licensing therapeutic patents to the highest bidder is counterproductive to this aim, as it prioritizes income maximizati...
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014) [0.03%]
人类免疫缺陷病毒Ⅰ型整合酶非催化位点抑制剂LEDGINs的专利研究(2006-2014)
Jonas Demeulemeester,Patrick Chaltin,Arnaud Marchand et al.
Jonas Demeulemeester et al.
Introduction: Integration of the viral genome into the host cell chromatin is a central step in the replication cycle of the HIV. Blocking the viral integrase (IN) enzyme therefore provides an attractive therapeutic strat...
Sheena Francis,Rupika Delgoda
Sheena Francis
Introduction: CYP, a ubiquitous superfamily of enzymes expressed in major organs in humans, plays a key role in biosynthesis of steroids and metabolism of xenobiotics. Inhibitors of these vital enzymes provide, as tools, ...
Amy C Anderson,Dennis L Wright
Amy C Anderson
Introduction: The folate biosynthetic pathway, responsible for the de novo synthesis of thymidine and other key cellular components, is essential in all life forms and is especially critical in rapidly proliferating cells...
Retiferols - synthesis and biological activity of a conceptually novel class of vitamin D analogs [0.03%]
新型维生素D类似物类化合物雷替菲醇的合成和生物活性研究
Narasimha Rao Bolla,Ewa Marcinkowska,Geoffrey Brown et al.
Narasimha Rao Bolla et al.
Introduction: The hypothesis that retiferols are a novel class of vitamin D analogs with therapeutic potential has been recently proved. The CD-ring of vitamin D, originated from a steroid precursor, is not necessary for ...
Enrique L Larghi,Teodoro S Kaufman
Enrique L Larghi
Introduction: The architecture of the complement system has evolved during the last 600 - 700 million years to become an amazingly efficient and highly versatile alerting and cell killing device. Under physiological condi...
Stefanie Bühler,Stefan A Laufer
Stefanie Bühler
Introduction: The p38 MAPK is a ubiquitous target in the research-based pharmaceutical industry. It plays a decisive role in the regulation of the production of proinflammatory cytokines. Since novel biological therapies ...
Hong-Yu Yuan,Xue-Hui Zhang,Xiao-Lan Zhang et al.
Hong-Yu Yuan et al.
Introduction: The incidence of gout and hyperuricemia has been increasing. The demand for new anti-gout therapies today presents exciting opportunities to organizations and individuals offering such products. ...