Bin Zhang,Xi Li,Bin Li et al.
Bin Zhang et al.
Introduction: Acridine derivatives have been extensively explored as potential therapeutic agents for the treatment of a number of diseases, such as cancer, Alzheimer's, and bacterial and protozoan infections. Their mode ...
A patent review of glucokinase activators and disruptors of the glucokinase--glucokinase regulatory protein interaction: 2011-2014 [0.03%]
2011-2014年己批准的糖原激酶激活剂及干预糖原激酶-糖原激酶调节蛋白相互作用专利评述
Kevin J Filipski,Jeffrey A Pfefferkorn
Kevin J Filipski
Introduction: Glucokinase (GK) is a key regulator of glucose homeostasis, and development of small molecule activators of this enzyme represents a promising new approach for the treatment of type 2 diabetes mellitus. ...
Sumit S Patil,Aliasgar Shahiwala
Sumit S Patil
Introduction: Oral-controlled and modified-release drug delivery systems with zero-order sustained-release kinetics have been developed and proven suitable for meeting increasingly sophisticated therapeutic needs. Neverth...
Tropomyosin receptor kinase inhibitors: a patent update 2009 - 2013 [0.03%]
关于神经营养因子受体酪氨酸激酶抑制剂的专利更新(2009-2013)
Clive McCarthy,Edward Walker
Clive McCarthy
Introduction: Tropomyosin receptor kinases (Trks) are a family of three similar tyrosine kinases activated by peptide hormones of the neurotrophin family. The nerve growth factor antibody tanezumab has provided clinical p...
Anti-CD44 mAb for the treatment of B-cell chronic lymphocytic leukemia and other hematological malignancies: evaluation of WO2013063498 [0.03%]
抗CD44单克隆抗体在B细胞慢性淋巴细胞性白血病和其他血液系统恶性肿瘤治疗中的应用:评估WO2013063498专利申请书
Giovanni DArena,Gioacchino Calapai,Silvia Deaglio
Giovanni DArena
Introduction: The CD44 transmembrane glycoprotein family mediates cellular responses to the microenvironment through binding of hyaluronic acid (HA) and other proteins of the extracellular matrix. These interactions start...
Research and development of anti-Alzheimer's drugs: an analysis based on technology flows measured by patent citations [0.03%]
基于专利引文衡量的技术流动视角下的阿尔茨海默病药物研发能力分析
Jiachen Xu,Xiangjun Kong,Lan Qiu et al.
Jiachen Xu et al.
Introduction: Alzheimer's disease (AD) is a serious illness with dramatically increasing incidence. Tremendous worldwide efforts have been exerted to find better ways to treat the disease, delay its onset and prevent it f...
Santiago Grijalvo,Anna Aviñó,Ramon Eritja
Santiago Grijalvo
Introduction: The use of aptamers, antisense technology and RNA interference has allowed nucleic acids to be considered as promising alternatives to classical drugs. However, nucleic acids face several obstacles in the cr...
Targeting monocyte and macrophage subpopulations for immunotherapy: a patent review (2009 - 2013) [0.03%]
针对单核细胞和巨噬细胞亚群的免疫治疗:2009-2013年的专利回顾
William D Jackson,Kevin J Woollard
William D Jackson
Introduction: Monocytes and macrophages are heterogeneous populations of effector cells in the innate immune system. Once thought to be obligatory precursors for macrophages, monocytes are now known to have several distin...
HAGE, the helicase antigen as a biomarker for breast cancer prognosis (WO2013144616) [0.03%]
Helicase抗原作为乳腺癌预后的生物标志物(WO2013144616)
Michael Wiese,Ilza K Pajeva
Michael Wiese
Introduction: Breast cancer (BC) is the most common cancer in women and it ranks second as a cause of cancer death in women (after lung cancer). The receptor-based diagnosis of BC tumors allows application of more individ...
Novel thiazole derivatives: a patent review (2008 - 2012. Part 2) [0.03%]
新型噻唑衍生物专利回顾(2008-2012年.第二部分)
Alberto Leoni,Alessandra Locatelli,Rita Morigi et al.
Alberto Leoni et al.
Introduction: Thiazole is a well-known five-membered heterocyclic compound. Various methods have been worked out for its synthesis. In the last few decades, a lot of work has been done on the thiazole ring to find new dru...