Current perspectives on the therapeutic aspects of chronic myelogenous leukemia [0.03%]
慢性粒细胞白血病治疗方面的最新观点
Asiem Bhaskar,Kiran Raturi,Shweta Dang et al.
Asiem Bhaskar et al.
Introduction: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder arising from the malignant transformation of normal myeloid cells. Its genetic hallmark is the presence of Philadelphia chromosome transloc...
PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011 - 2014) [0.03%]
2型糖尿病治疗中PTP1B抑制剂专利回顾（2011-2014）
Akhilesh Kumar Tamrakar,Chandan K Maurya,Amit K Rai
Akhilesh Kumar Tamrakar
Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the negative regulation of insulin signal transduction pathway and has emerged as novel therapeutic strategy for the treatment of type 2 dia...
Recent patents on calcium channel blockers: emphasis on CNS diseases [0.03%]
近年钙离子通道阻滞剂专利综述：重点介绍中枢神经系统疾病治療方面的进展
Juan-Alberto Arranz-Tagarro,Cristóbal de los Ríos,Antonio G García et al.
Juan-Alberto Arranz-Tagarro et al.
Introduction: Altered homeostasis of cell calcium movement is a central stage in multiple diseases of CNS. This explains the great therapeutic interest in blockers for the various subtypes of voltage-activated calcium cha...
Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review [0.03%]
focal粘附激酶抑制剂在转移性癌症治疗中的应用：专利分析
Ekambaram Shanthi,Mudeenahally H Krishna,Gubbi M Arunesh et al.
Ekambaram Shanthi et al.
Introduction: Focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation increases phosphorylation of Tyr397 and other sites of the protein. FAK-dependent activation of signaling pathways imp...
Helen Blanchard,Xing Yu,Patrick Michael Collins et al.
Helen Blanchard et al.
Introduction: Galectin-3 (Gal-3), a lectin with preference for β-galactoside-containing carbohydrates, is a structurally unique member of the galectin family. It is ubiquitously expressed in various mammalian tissues wit...
Therapeutic applications of lipoic acid: a patent review (2011 - 2014) [0.03%]
硫辛酸的治疗应用：专利综述(2011-2014)
Maria Koufaki
Maria Koufaki
Introduction: Lipoic acid (LA), a naturally occurring 1,2-dithiolane analog that plays an essential role in mitochondrial bioenergetic reactions, has gained unprecedented attention as nutritional supplement and as therape...
Nian-Guang Li,Yu-Ping Tang,Jin-Ao Duan et al.
Nian-Guang Li et al.
Introduction: The MMPs are involved in tissue remodeling. An imbalance between the inhibition and activation of MMPs results in excessive degradation of the extracellular matrix, which leads to some diseases including can...
John A Tessensohn
John A Tessensohn
Japan has made 'innovation in science and technology' as one of its central pillars to ensure high growth in its next stage of economic development and its life sciences market which hosts regenerative medicine was proclaimed to be 'the bes...
Graham S Timmins
Graham S Timmins
Introduction: Deuterated versions of existing drugs can exhibit improved pharmacokinetic or toxicological properties due the stronger deuterium- carbon bond modifying their metabolism. There is great interest in the curre...
Luca Costantino,Daniela Barlocco
Luca Costantino
Introduction: Over the past 3 years, several patents appeared dealing with the discovery of compounds able to modulate ghrelin actions: agonists for the treatment of cachexia, as diagnostic agents for GH deficiency or for...