miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650 [0.03%]
微小核糖核酸作为帕金森氏症的新治疗标靶及诊断生物标记：评估WO2014018650专利申请书
Marlen Hesse,Christoph Arenz
Marlen Hesse
Introduction: Parkinson's disease (PD) requires novel means for early-stage recognition, enabling early therapeutic approaches. Since microRNAs (miRNAs) are important components of the gene regulatory networks in neurodeg...
Biosimilars lining up to compete with Herceptin--opportunity knocks [0.03%]
赫赛汀迎来竞争者biosimilar登场良机来临
Kevin M Nelson,Patrick C Gallagher
Kevin M Nelson
Trastuzumab is a monoclonal antibody developed by Genentech as a treatment for breast cancer and gastric cancer when the cancer cells overexpress HER2, a membrane-bound receptor activated by epidermal growth factor. Now marketed by Roche un...
Caffeic acid derivatives, analogs and applications: a patent review (2009-2013) [0.03%]
咖啡酸衍生物、类似物及应用专利回顾（2009-2013）
Tiago Silva,Catarina Oliveira,Fernanda Borges
Tiago Silva
Introduction: Caffeic acid (CA) is broadly distributed in several species of the plant kingdom and is widely consumed in human diet. CA and derivatives have been extensively studied in the past years, which unveiled a bro...
cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases [0.03%]
环核苷酸磷酸二酯酶家族的cAMP特异性成员：炎症和神经性疾病药物治疗的新希望
Ana Martinez,Carmen Gil
Ana Martinez
Introduction: PDEs are key enzymes in the adenosine and guanosine cyclic nucleotides (cAMP and cGMP) signaling cascade. Their inhibition increases cyclic nucleotide levels inside the cell. Thus, pharmacological modulation...
Hemalatha Beesetti,Navin Khanna,Sathyamangalam Swaminathan
Hemalatha Beesetti
Introduction: Almost half the global population is estimated to be at risk of contracting dengue infection. Of the 400 million infections estimated to occur annually, 4 million can be potentially life-threatening leading ...
Loranne Agius
Loranne Agius
The concept of activation of glucokinase (encoded by the Gck gene) as a potential therapy for type 2 diabetes has been explored by several pharmaceutical companies. Small-molecule Gck activators (GKAs) were found to be effective at increasi...
Prolinamide derivatives as thrombin inhibitors for the treatment of thrombin-mediated diseases: a patent evaluation of US2013296245 [0.03%]
用于血栓病治疗的血栓素抑制剂类脯氨酸衍生物专利分析：US2013296245
Zhi-Hao Shi,Nian-Guang Li,Yu-Ping Tang et al.
Zhi-Hao Shi et al.
Introduction: Thrombotic disorders can lead to deep vein thrombosis, myocardial infarction and stroke. Thrombin plays a vital role in cascade reaction of blood coagulation, inhibition of the activity of thrombin can block...
Andrographolide: progression in its modifications and applications - a patent review (2012 - 2014) [0.03%]
andrographolide的修饰及应用进展(2012-2014)-专利盘点综述
Chantana Aromdee
Chantana Aromdee
Introduction: Extraction, isolation and modifications of andrographolide (Androg) is extensively investigated and patented. The prominent activities were vastly modified for anticancer and antivirals. Many products relate...
Novel histamine H4 receptor ligands and their potential therapeutic applications: an update [0.03%]
组胺H4受体配体及其潜在治疗应用的新进展
Róbert Kiss,György M Keseru
Róbert Kiss
Introduction: Histamine H4 receptor (H4R) has been shown to be involved in various inflammatory conditions. Ligands acting on H4R show therapeutic potential in various diseases. For the first time, the positive proof-of-c...
Rodolfo do Couto Maia,Roberta Tesch,Carlos Alberto Manssour Fraga
Rodolfo do Couto Maia
Introduction: The N-acylhydrazone (NAH) moiety has been characterized as a privileged structure, capable of providing ligands points for more than one type of bioreceptor. Modifications of the subunits bonded to its acyl ...