Innate immune proteins as biomarkers for CNS injury: critical evaluation (WO2013119673 A1) [0.03%]
先天免疫蛋白作为中枢神经系统损伤生物标志物的重要评价（专利申请号：WO2013119673 A1）
Mithilesh Kumar Jha,Ho-Won Lee,Sang Yun Kim et al.
Mithilesh Kumar Jha et al.
Introduction: Injuries to the CNS represent a major global health problem. CNS injuries cause the elevation of many proteins, including innate immune proteins in biological fluids, such as the cerebrospinal fluid (CSF). T...
Teva Pharmaceuticals v. Sandoz: availability of generic glatiramer acetate and the impact to patent litigation claim construction [0.03%]
梯瓦公司诉山德士公司：醋酸格拉替雷仿制药的可及性及其对专利诉讼索赔解读的影响
Louis E Fogel,Chad J Ray
Louis E Fogel
In the upcoming case of Teva Pharmaceuticals v. Sandoz, the U.S. Supreme Court will address how much deference the appellate court should afford to a trial court's claim construction ruling. The effect of this decision will be far-reaching,...
Triggering receptor expressed on myeloid cells receptor family modulators: a patent review [0.03%]
趋化因子受体家族调节剂：专利评审
Christopher J Pelham,Amit N Pandya,Devendra K Agrawal
Christopher J Pelham
Introduction: Triggering receptor expressed on myeloid cells (TREM) receptors and TREM-like transcript (TLT; or TREML) receptors of the immunoglobulin superfamily are known as key modulators of host immune responses. TREM...
Katie L Strong,Yao Jing,Anthony R Prosser et al.
Katie L Strong et al.
Introduction: The NMDA receptor mediates a slow component of excitatory synaptic transmission, and NMDA receptor dysfunction has been implicated in numerous neurological disorders. Thus, interest in developing modulators ...
Peng Teng,Haifan Wu,Lili Lin et al.
Peng Teng et al.
The patent application WO2013112548 claims a new class of peptidomimetics - γ-AApeptides with potent and broad-spectrum antimicrobial activity. These γ-AApeptides are active against both Gram-positive and Gram-negative bacteria, including...
Anna-Maria Katsori,Dimitra Hadjipavlou-Litina
Anna-Maria Katsori
Introduction: Coumarins belong to the benzopyrones family. They are naturally plant-derived and synthetically taken polyphenolic substances, presenting a wide variety of biological activities and behaviours, supporting th...
Introduction of a nitrogen-containing side chain appended on C-10 of cethromycin leads to reduced CYP3A4 inhibition (WO2014049356A1) [0.03%]
卡泊霉素C-10位氮取代衍生物作为免疫抑制剂和抗菌剂的作用
Jian-Hua Liang
Jian-Hua Liang
Introduction: Infections caused by antibiotic-resistant bacteria pose an increasing risk for clinical treatment. Macrolide-lincosamide-streptogramin B is becoming increasingly ineffective due to the methylation at the bin...
Evaluation of WO2014075392 and WO2014075393, Merck's first PI3Kδ inhibitor filings [0.03%]
关于默克公司第一组PI3Kδ抑制剂WO2014075392和WO2014075393的评估研究论文发表
Peter Norman
Peter Norman
Introduction: There is considerable interest in the development of selective PI3Kδ inhibitors for the treatment of inflammatory diseases and haematological cancers. Merck has no previous filings in this field but license...
Vijay K Singh,Victoria L Newman,Patricia L P Romaine et al.
Vijay K Singh et al.
Introduction: Despite significant scientific advances over the past 60 years towards the development of a safe, nontoxic and effective radiation countermeasure for the acute radiation syndrome (ARS), no drug has been appr...
Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011-2014) [0.03%]
新型HIV-1非核苷类逆转录酶抑制剂：2011年至2014年专利回顾
Xiao Li,Lingzi Zhang,Ye Tian et al.
Xiao Li et al.
Introduction: There is a continuous need for next-generation non-nucleoside RT inhibitors (NNRTIs) with different resistance profiles, improved safety, excellent tolerability, and favorable physicochemical properties. ...