Peng-Cheng Lv,Hai-Liang Zhu
Peng-Cheng Lv
Peptide ligands have many desirable features enabling them to act as drug molecules and are valuable in the drug discovery processes because of their fewer side effects and great potential to cure diseases. In this patent, three kinds of pe...
Respivert's multikinase inhibitors, an evaluation of WO2014033446 to WO2014033449 [0.03%]
关于专利WO2014033446至WO2014033449的Respivert多激酶抑制剂的评价
Peter Norman
Peter Norman
These four patent applications all claim that N-aryl-N'-pyrazol-5-yl urea derivatives , related to RV-568, which are inhibitors of p38, Syk and Src kinases. All four applications claim their use in the treatment of inflammatory diseases, no...
Orexin receptor antagonists--a patent review (2010 to August 2014) [0.03%]
嗜络促红细胞生成素受体拮抗剂专利回顾（2010年8月-2014年）
Christoph Boss
Christoph Boss
Introduction: The orexin (hypocretin) system is an evolutionarily conserved neuropeptide-G-protein-coupled receptor system, consisting of two neuropeptides the orexin-A and the orexin-B peptides as well as two receptors t...
'Click chemistry' for diagnosis: a patent review on exploitation of its emerging trends [0.03%]
点击化学在疾病诊断中的应用及专利分析：新兴技术发展趋势综述
Anita Mandhare,Paromita Banerjee,Smita Bhutkar et al.
Anita Mandhare et al.
Introduction: Click chemistry is the novel synthetic approach towards developing reactions with large thermodynamic driving forces to give almost complete conversion of new molecular reagents to a single product. Thus, cl...
Is the European Patent Office's approach to assessing obviousness of antibody inventions consistent? [0.03%]
欧洲专利局关于抗体发明显而易见性评判标准的一致性如何？
Barbara Rigby
Barbara Rigby
Antibodies can be highly effective in the diagnosis and/or treatment of a wide range of diseases, including certain cancers, viral infections and inflammatory diseases. The development of any new therapeutic antibody is very time consuming,...
Novel monoamine oxidase inhibitors: a patent review (2012 - 2014) [0.03%]
新颖的单胺氧化酶抑制剂专利回顾(2012-2014)
Simone Carradori,Jacobus P Petzer
Simone Carradori
Introduction: Monoamine oxidase (MAO) inhibitors, despite the initial pharmacological interest, are used in clinic for their antidepressant effect and in the management of Parkinson symptoms, due to the established neurop...
Isaac O Donkor
Isaac O Donkor
Introduction: Calpain is a family of cysteine proteases found in eukaryotes and a few bacteria. There is considerable interest in the search for calpain inhibitors because the enzyme has been implicated in several disease...
How would patent reform legislation in the United States impact the pharmaceutical industry? [0.03%]
美国《专利改革法案》将对医药行业产生何种影响？
Andrew W Williams
Andrew W Williams
The United States Congress is attempting to tackle a perceived problem with so-called 'patent trolls' by introducing legislation directed at the particular traits attributable to these patent holders. Two of these proposed provisions involv...
Histone deacetylase inhibitors for enhancing activity of antifungal agent: a patent evaluation of WO2014041424(A1) [0.03%]
组蛋白去乙酰化酶抑制剂增强抗真菌药的活性：WO2014041424(A1)专利点评
Lei Zhang,Wenfang Xu
Lei Zhang
Novel histone deacetylase inhibitors have been developed for the antifungal therapy. Molecule 8 exhibited potent antifungal activities with MIC values of 0.25/0.25, 0.12/0.25, 0.12/0.12 µg/ml against Candida albicans, C. parapsilosis and C...
Nitric oxide synthase inhibitors: a review of patents from 2011 to the present [0.03%]
一氧化氮合酶抑制剂：2011年至今专利回顾
Yanyan Yang,Tao Yu,Yu-Ji Lian et al.
Yanyan Yang et al.
Introduction: Nitric oxide synthases (NOSs) are a family of enzymes that play an essential role in synthesizing nitric oxide (NO) by oxidizing l-arginine. As previously reported, NO is a significant mediator in cellular s...