Nisheeth C Desai,Unnat P Pandit,Amit Dodiya
Nisheeth C Desai
Introduction: The prevalence of metabolic syndrome, obesity and insulin resistance has become an epidemic. Thiazolidinediones (TZDs) affect glucose and lipid metabolism in insulin-sensitive tissues, which in turn reduces ...
Mairim R Serafini,Adriana G Guimarães,Jullyana S S Quintans et al.
Mairim R Serafini et al.
Introduction: Ultraviolet irradiation has deleterious effects on human skin, including tanning, sunburn, cancer and connective tissue degradation (photoaging). Botanical antioxidants have been shown to be associated with ...
Therapeutic potential of peroxynitrite decomposition catalysts: a patent review [0.03%]
过氧亚硝酸根分解催化剂的治疗潜力：专利综述
Lauren M Slosky,Todd W Vanderah
Lauren M Slosky
Introduction: Peroxynitrite is a cytotoxic oxidant species implicated in a host of pathologies, including inflammatory and neurodegenerative diseases, cancer, radiation injury and chronic pain. With the recognition of the...
Frédéric Couture,Anna Kwiatkowska,Yves L Dory et al.
Frédéric Couture et al.
Introduction: Since the discovery of furin, numerous reports have studied its role in health and diseases, including cancer, inflammatory and infectious diseases. This interest has led to the development of both large pro...
Sateesh Kumar Arepalli,Minho Choi,Jae-Kyung Jung et al.
Sateesh Kumar Arepalli et al.
Importance of the field: The NF-κB family of transcription factors has a vital role in coordinating the expression of a wide variety of genes that control immune responses. The dysfunction of NF-κB has been associated w...
Valentina Zuliani,Alberto Rapalli,Manoj K Patel et al.
Valentina Zuliani et al.
Introduction: Abnormal activity of voltage-gated sodium channels (VGSCs) is related to several pathological processes, including cardiac arrhythmias, epilepsy, cancer, neurodegenerative diseases, spasticity, chronic and n...
Screening methods for AMP-activated protein kinase modulators: a patent review [0.03%]
AMP活化蛋白激酶调节剂的筛选方法：专利回顾
Joungmok Kim,Joonsoo Shin,Joohun Ha
Joungmok Kim
Introduction: AMP-activated protein kinase (AMPK) functions as a cellular energy gauge that maintains cellular homeostasis and has been suggested to play important roles in tumorigenesis, lifespan and autophagy. According...
New perspectives for leishmaniasis chemotherapy over current anti-leishmanial drugs: a patent landscape [0.03%]
当今抗利什曼病药物的新视角：专利格局概览
Alice Machado-Silva,Pedro Pires Goulart Guimarães,Carlos Alberto Pereira Tavares et al.
Alice Machado-Silva et al.
Introduction: Although leishmaniasis is estimated to cause the ninth largest disease burden among individual infectious diseases, it is still one of the most neglected diseases in terms of drug development. Current drugs ...
Martin Dolezal,Jan Zitko
Martin Dolezal
Introduction: Pyrazine is a member of 1,4-diazines, which constitute an important class of heterocycles. Various pyrazine derivatives have been synthesized and successfully evaluated as agents with diverse pharmacological...
Anders Johansson,Christian Löfberg
Anders Johansson
Introduction: The cyclic neuropeptide melanin-concentrating hormone (MCH) shows appetite-stimulating effects indicating an involvement in obesity. Large efforts have been invested in discovery programs to identify novel M...