New substituted benzimidazole derivatives: a patent review (2013 - 2014) [0.03%]
新型取代苯并咪唑衍生物专利回顾（2013-2014）
Miao Wang,Xiaofeng Han,Zhiming Zhou
Miao Wang
Introduction: The benzimidazole nucleus is found in a variety of naturally occurring compounds and is of significant importance in medicinal chemistry. Owing to its conspicuous pharmacological properties, benzimidazoles h...
Nicolas Gaboriaud-Kolar,Konstantina Vougogiannopoulou,Alexios-Leandros Skaltsounis
Nicolas Gaboriaud-Kolar
Introduction: Indirubins are bisindole alkaloids naturally occurring in indigo-bearing plants or in mollusks from the Muricidae family. They belong to the rather small family of indigoids, which has nevertheless found an ...
Novel therapeutic uses and formulations of botulinum neurotoxins: a patent review (2012 - 2014) [0.03%]
肉毒杆菌素的新治疗用途及剂型专利点评（2012-2014）
Christopher D Kane,Jonathan E Nuss,Sina Bavari
Christopher D Kane
Introduction: Botulinum neurotoxins (BoNTs) are among the most toxic of known biological molecules and function as acetylcholine release inhibitors and neuromuscular blocking agents. Paradoxically, these properties also m...
Small molecule glucagon receptor antagonists: a patent review (2011 - 2014) [0.03%]
小分子胰高血糖素受体拮抗剂专利回顾(2011-2014)
Kevin J Filipski
Kevin J Filipski
Introduction: Glucagon receptor antagonists (GCGRAs) have been an area of ongoing research in the pharmaceutical industry for more than two decades. Blocking the action of the glucagon peptide leads to repression of hepat...
Mike Snodin
Mike Snodin
Ever since the introduction of the 'Bolar' exemption into the national laws of the EU Member States, the UK has been perceived to be a relatively difficult territory in which to conduct clinical trials, as compared to EU territories having ...
Iron oxide-based multifunctional nanoparticulate systems for biomedical applications: a patent review (2008 - present) [0.03%]
基于氧化铁的多功能纳米颗粒系统在生物医学应用中的专利回顾(2008-至今)
Mazen M El-Hammadi,José L Arias
Mazen M El-Hammadi
Introduction: Iron oxide nanoparticles (IO NPs) exhibit remarkable properties, including inherent magnetism, biocompatibility, high surface to volume ratio, and versatility of engineering, making them ideal candidates for...
Yoshikazu Uto
Yoshikazu Uto
Introduction: Benzisoxazoles represent a class of heterocyclic compounds of great importance for the preparation of biologically active compounds. Benzisoxazoles are an important structure and some benzisoxazole-based med...
MicroRNA-145-targeted drug and its preventive effect on pulmonary arterial hypertension (patent WO2012153135 A1) [0.03%]
一种用于预防肺动脉高压的miR-145靶向药物及其应用（专利申请号：WO2012153135 A1）
Natalia Ogorodnikova,Christoph Arenz
Natalia Ogorodnikova
Introduction: Pulmonary arterial hypertension (PAH) is a disease of various etiologies, characterized by progressive vascular remodeling that leads to right ventricular hypertrophy and heart failure. Although modern thera...
Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014) [0.03%]
血管加压素v1a和v1b受体调节剂专利回顾（2012-2014）
Magdalena J Ślusarz
Magdalena J Ślusarz
Introduction: The vasopressin V1a and V1b receptors are involved in many crucial physiological, reproductive, behavioral and social functions. Consequently, they are also involved in several pathological conditions, thus ...
Targeting GLI proteins in human cancer by small molecules (WO2014116651 A1): a patent evaluation [0.03%]
靶向作用于人类癌症中小分子的GLI蛋白（WO2014116651 A1）：一项专利评估
M Kyle Hadden
M Kyle Hadden
The invention reviewed in this patent evaluation is the synthesis and application of small molecule inhibitors of Gli transcriptional activity as potential anticancer agents. The oncogenic nature of Gli proteins has been traditionally assoc...