3-Hydroxy-3-methylglutaryl-coenzyme A reductase modulator: toward age- and sex-personalized medicine [0.03%]
3-羟基-3-甲基谷固醇-O-酰辅酶A还原酶调节剂：朝向年龄与性别个性化医疗
Valentina Pallottini
Valentina Pallottini
Cholesterol homeostasis maintenance is regulated by a cellular feedback system that senses cholesterol amount in cellular membranes. 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMGR) plays a pivotal role in cholesterol metabolism as it...
Patents for Toll-like receptor ligands as radiation countermeasures for acute radiation syndrome [0.03%]
用于急性放射病的 toll 样受体配体辐射防护专利研究
Vijay K Singh,Harvey B Pollard
Vijay K Singh
Acute radiation exposure induces apoptosis of tissues in the hematopoietic, digestive, cutaneous, cardiovascular and nervous systems; extensive apoptosis of these tissues ultimately leads to acute radiation syndrome. A novel strategy for de...
Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014) [0.03%]
中性粒细胞弹性蛋白酶抑制剂：专利综述及其在炎症性肺病中的潜在应用（2010-2014）
Yung-Fong Tsai,Tsong-Long Hwang
Yung-Fong Tsai
Introduction: The proteolytic activity of neutrophil elastase (NE) not only destroys pathogens but also degrades host matrix tissues by generating a localized protease-antiprotease imbalance. In humans, NE is well known t...
Treatment of obesity and pulmonary arterial hypertension with inhibitors of the prostaglandin transporter: evaluation of patent WO2014/204895A1 [0.03%]
前列腺素转运体抑制剂治疗肥胖症和肺动脉高压的专利评估WO2014/204895A1）
Jasper Dingemanse,Martin Bolli,Marc Iglarz
Jasper Dingemanse
Prostaglandins display a wide array of pharmacological effects and prostaglandin analogs are already used in the treatment of pulmonary arterial hypertension (PAH). After synthesis and release from cells, prostaglandins undergo reuptake by ...
Pershang Farshi,Rahul R Deshmukh,Joseph O Nwankwo et al.
Pershang Farshi et al.
Introduction: Deubiquitinating-enzymes (DUBs) are key components of the ubiquitin-proteasome system (UPS). The fundamental role of DUBs is specific removal of ubiquitin from substrates. DUBs contribute to activation/deact...
Positive airway pressure and electrical stimulation methods for obstructive sleep apnea treatment: a patent review (2005 - 2014) [0.03%]
用于阻塞性睡眠呼吸暂停治疗的正压通气和电刺激方法专利分析（2005-2014）
Daniel Álvarez,Gonzalo C Gutiérrez-Tobal,Félix Del Campo et al.
Daniel Álvarez et al.
Introduction: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a major health problem with significant negative effects on the health and quality of life. Continuous positive airway pressure (CPAP) is currently the pr...
Analysis of patents on anti-rheumatoid arthritis therapies issued in China [0.03%]
中国颁发的抗类风湿性关节炎疗法的专利分析
Hong-Yu Yuan,Xiao-Lan Zhang,Xue-Hui Zhang et al.
Hong-Yu Yuan et al.
Introduction: The etiology of rheumatoid arthritis (RA) is complex and diverse. Chronic inflammatory processes with joint dysfunction can cause permanent disability. Therefore, the development of new drugs and therapies f...
Thomas Durek,David J Craik
Thomas Durek
Introduction: Conotoxins are a large family of bioactive peptides derived from cone snail venom. They target specific classes of ion channels and other membrane proteins and may have therapeutic value, primarily in the ma...
Methods for treating IL-6-related diseases (US2015010554A1): a patent evaluation [0.03%]
IL-6相关疾病的治疗方法（US2015010554A1）：一项专利评估
Young-Won Chin
Young-Won Chin
Introduction: IL-6 is involved in a variety of diseases such as acute or chronic inflammation and autoimmune diseases, and the modulation of IL-6 level is recognized as an important target. Therefore, the blocking agent o...
Chris J van Koppen,Rolf W Hartmann
Chris J van Koppen
Introduction: About 2% of the Western world population suffer from chronic wounds, resulting from underlying disorders (e.g., diabetes, excessive pressure, vascular insufficiencies and vasculitis), with a significant adve...