Carmela De Luca
Carmela De Luca
Merck recently signed an agreement with The Medicines Patent Pool (MPP) to license intellectual property relating to pediatric formulations of its integrase HIV drug, raltegravir (Ral) (the 'Agreement'). The Agreement is alleged to clear th...
Valentina Sepe,Eleonora Distrutti,Stefano Fiorucci et al.
Valentina Sepe et al.
Introduction: Farnesoid-X-receptor (FXR) is the receptor for primary bile acids expressed in enterohepatic tissues where it regulates bile acid uptake, metabolism and disposal. For its role as a bile acid sensor, FXR has ...
Small molecule and peptide therapies for chronic heart failure: a patent review (2011 - 2014) [0.03%]
慢性心力衰竭的小分子和肽类疗法专利回顾（2011-2014）
Brian Raymer,David Ebner
Brian Raymer
Introduction: Chronic heart failure (CHF) is the long-term inability of the heart to meet circulatory demands under normal conditions. Effects of CHF can include increased blood volume, increased vascular resistance and c...
Esmeralda Carrillo,Saúl Abenhamar Navarro,Alberto Ramírez et al.
Esmeralda Carrillo et al.
Introduction: 5-Fluorouracil (5-FU)-based chemotherapy is the most widely prescribed treatment for gastrointestinal solid tumors, but there are several drawbacks such as toxicities, lack of selectivity and effectiveness a...
A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents [0.03%]
大麻素1型受体拮抗剂作为抗肥胖药物的专利评审综合述评
Mayank Kumar Sharma,Prashant R Murumkar,Mahesh A Barmade et al.
Mayank Kumar Sharma et al.
Introduction: Obesity is a rapidly expanding worldwide health problem. Various targets are investigated presently for the treatment of obesity, but there remains an unmet need for an effective drug therapy with acceptable...
Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014) [0.03%]
细胞周期依赖性激酶在癌症治疗中的作用：一项关于专利的综述(2009-2014)
Veronika Malínková,Jakub Vylíčil,Vladimír Kryštof
Veronika Malínková
Introduction: Cell cycle deregulation is a common characteristic of cancer cells. Progression through the cell cycle is controlled by enzymes known as cyclin-dependent kinases (CDKs), whose activity can be upregulated by ...
Retinoid-related orphan receptor γ t modulators: comparison of Glenmark's me-too patent application (WO2015008234) with the originator application from Merck Sharp and Dohme (WO2012106995) [0.03%]
比较默克和辉瑞的同靶点专利申请：格伦马克的跟随者申请（WO2015008234）与原研者默克的申请（WO2012106995）
Christian Gege
Christian Gege
Retinoic acid receptor-related orphan nuclear receptor γ t (RORγt) is a key transcription factor for the development of TH17 cells. Inhibiting RORγt activity is thought to be beneficial in targeting a variety of inflammatory and autoimmu...
Transdermal delivery of therapeutic agents using dendrimers (US20140018435A1): a patent evaluation [0.03%]
树状分子经皮给药（US20140018435A1）：专利分析与评价
Jiepin Yang,Jingjing Hu,Binwei He et al.
Jiepin Yang et al.
Transdermal drug delivery offers a number of advantages over systematic administrations such as oral administration and intravenous injection. However, most therapeutic agents are limited in transdermal delivery due to the presence of a str...
Phillip Dixon,Chancellor Shafor,Samuel Gause et al.
Phillip Dixon et al.
Introduction: Ophthalmic drugs are almost exclusively delivered via eye drops in spite of several deficiencies, including low bioavailability and poor compliance. Contact lenses have the potential to increase bioavailabil...
Developments in inhaled combination therapies: patent activity 2013-2014 [0.03%]
吸入给药复方疗法的专利动向(2013-2014)
Peter Norman
Peter Norman
Introduction: Since the 1970s, the treatment options for asthma and chronic obstructive pulmonary disease have increasingly relied upon the use of inhaled drug formulations, generally from handheld inhaler devices. The in...