Tahsin F Kellici,George Liapakis,Andreas G Tzakos et al.
Tahsin F Kellici et al.
Introduction: New drug formulations against hypertension have a vital role in the quality of human life, as this risk factor for cardiovascular disease can be life threatening. A modern life style characterized by less ex...
Tao Yu,Yanyan Yang,De Qing Yin et al.
Tao Yu et al.
Introduction: TANK-binding kinase 1 (TBK1) is a noncanonical IκB kinase family member that regulates the innate immune response. Misregulation of TBK1 activity can promote inflammatory disorders and oncogenesis; therefor...
Humera Jahan,M Iqbal Choudhary
Humera Jahan
Introduction: The glycation process, comprising a series of reactions, results in the formation of heterogeneous adducts, known as advanced glycation end products (AGEs). AGEs are involved in several pathologies, includin...
Synthesis and pharmacological activities of non-flavonoid chromones: a patent review (from 2005 to 2015) [0.03%]
非黄酮查尔酮的合成及其药理活性专利文献回顾（2005-2015）
Maria João Matos,Saleta Vazquez-Rodriguez,Eugenio Uriarte et al.
Maria João Matos et al.
Introduction: Chromones are one of the major classes of naturally occurring compounds. Their chemistry has been widely explored and extensively reviewed. The following review intends to give a broad overview of the patent...
Synthesis and pharmacological activities of non-flavonoid chromones: a patent review (from 2005 to 2015) [0.03%]
非黄酮查耳酮的合成及药理活性专利回顾（2005-2015）
Maria João Matos,Saleta Vazquez-Rodriguez,Eugenio Uriarte et al.
Maria João Matos et al.
Introduction: Chromones are one of the major classes of naturally occurring compounds. Their chemistry has been widely explored and extensively reviewed. The following review intends to give a broad overview of the patent...
An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus [0.03%]
一项有关II型糖尿病新钠-葡萄糖协同转运蛋白2抑制剂的评估报告
Meiyan Jiang,Peter S Steyger
Meiyan Jiang
Introduction: Type 2 diabetes mellitus (T2DM) is a growing and serious global health problem. Pharmacological inhibition of the sodium-glucose cotransporter-2 (SGLT2; SLC5A2) increases urinary glucose excretion, decreasin...
An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus [0.03%]
评估美国专利2015065565(A1)：一类用于治疗II型糖尿病的新SGLT2抑制剂
Meiyan Jiang,Peter S Steyger
Meiyan Jiang
Introduction: Type 2 diabetes mellitus (T2DM) is a growing and serious global health problem. Pharmacological inhibition of the sodium-glucose cotransporter-2 (SGLT2; SLC5A2) increases urinary glucose excretion, decreasin...
Michael Wiese
Michael Wiese
Introduction: BCRP/ABCG2 is a polyspecific ATP binding cassette transporter involved in multidrug resistance of tumors. Compared with P-glycoprotein/ABCB1 only a few inhibitors are known. ...
Michael Wiese
Michael Wiese
Introduction: BCRP/ABCG2 is a polyspecific ATP binding cassette transporter involved in multidrug resistance of tumors. Compared with P-glycoprotein/ABCB1 only a few inhibitors are known. ...
Carmela De Luca
Carmela De Luca
Merck recently signed an agreement with The Medicines Patent Pool (MPP) to license intellectual property relating to pediatric formulations of its integrase HIV drug, raltegravir (Ral) (the 'Agreement'). The Agreement is alleged to clear th...