D Chavarria,T Silva,D Magalhães e Silva et al.
D Chavarria et al.
Introduction: Piperine is a simple and pungent alkaloid found in the seeds of black pepper (Piper nigrum). Following its isolation and full characterization, the biological properties of piperine have been extensively stu...
Modulation of tumor immunity: a patent evaluation of WO2015026684A1 [0.03%]
肿瘤免疫调节专利分析之WO2015026684A1号
Giuseppe Nocentini,Luigi Cari,Simona Ronchetti et al.
Giuseppe Nocentini et al.
A high percentage of regulatory T cells (Tregs) among tumor-infiltrating lymphocytes weakens the immune response against tumors. The anergy of effector T cells (Teff) can be reversed by immune checkpoint treatment, which inhibits Tregs and ...
Jeffrey W Keillor,Kim Y P Apperley
Jeffrey W Keillor
Introduction: Transglutaminases (TGases) are a class of enzymes that play multifunctional roles. Their protein-crosslinking activity has been linked to fibrosis and Huntington's disease, their glutamine deamidation activi...
Hamid Sadeghian,Atena Jabbari
Hamid Sadeghian
Introduction: 15-Lipoxygenases (15-LOXes) are a family of iron-containing proteins that have the capability for unsaturated fatty acid peroxidation in animals and plants. Two types of the enzyme, 15-LOX-1 and 15-LOX-2, ha...
RGD mimetics γ-AApeptides and methods of use (US 20,140,004,039 A1): a patent evaluation [0.03%]
关于RGD模拟物γ-AA肽及其用途（US 20,140,004,039 A1）的专利评估
Haifan Wu,Jinzhi Jiang,Hai Xu et al.
Haifan Wu et al.
The patent (US 20140004039 A1) claims Arg-Gly-Asp (RGD) mimetics based on a new type of peptidomimetics - γ-AApeptides - which display high binding affinity and specificity to integrin αvβ3. Integrin αvβ3 is one of the most important p...
Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1 [0.03%]
具有改善的溶解度的强大HIV-1非核苷逆转录酶抑制剂新型二芳基嘧啶和二芳基三嗪：对US20140378443A1专利的评估
Boshi Huang,Dongwei Kang,Jiapei Yang et al.
Boshi Huang et al.
Diarylpyrimidine and diaryltriazine derivatives, two representative structurally related classes of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with robust potencies against wild-type and several mutant strains of HIV-1, ...
Indole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1 [0.03%]
关于WO2015036412A1的专利分析：吲哚-2-甲酰胺衍生物
Jan Zitko,Martin Dolezal
Jan Zitko
Introduction: Hippocampal neurogenesis in adults is a new and attractive target for the treatment and prevention of neurodegenerative and neuro-psychiatric diseases. Recently, neurogenesis stimulating activity was observe...
Amorfrutins are efficient modulators of peroxisome proliferator-activated receptor gamma (PPARγ) with potent antidiabetic and anticancer properties: a patent evaluation of WO2014177593 A1 [0.03%]
amorfrutin是有效的过氧化物酶体增殖激活受体γ(PPARγ)调节剂，具有强大的抗糖尿病和抗癌特性：关于WO2014177593A1专利的评估
Antonio Lavecchia,Carmen Di Giovanni
Antonio Lavecchia
Introduction: PPARγ is an essential regulator of lipid, glucose, and insulin metabolism. PPARγ full agonists, such as thiazolidinediones, are the mainstay drugs for the treatment of type 2 diabetes; however, undesirable...
Maria Koufaki
Maria Koufaki
Introduction: The vitamin E family consists of four tocopherols and four tocotrienols. α-Tocopherol is the most studied member of this family for its antioxidant and non-antioxidant properties, while tocotrienols have at...
Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1) [0.03%]
一种专利评估：WO2015048311（A1）具有细胞色素P450抑制作用的新功能化5-（苯氧基甲基）-1,3-二氧杂环烷类似物
Richard L Schroeder,Phan Tram,Jiawang Liu et al.
Richard L Schroeder et al.
Cytochrome P450's (CYP's) constitute a diverse group of over 500 monooxygenase hemoproteins, catalyzing transformations that involve xenobiotic metabolism, steroidogenesis and other metabolic processes. Over-production of the steroid hormon...