Pharmacological effects of berberine and its derivatives: a patent update [0.03%]
小檗碱及其衍生物的药理作用：专利更新
Yifeng Jin,Daulat B Khadka,Won-Jea Cho
Yifeng Jin
Introduction: A number of plant-derived agents are used in many therapeutic areas. Berberine, an important protoberberine alkaloid, is present in a number of medicinal plants that have been widely used in traditional Chin...
Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014) [0.03%]
五羟色胺受体2(5-HT2R)激动剂和拮抗剂专利回顾（2004-2014）
Yang Yang,Shu An,Ying Liu et al.
Yang Yang et al.
Introduction: Serotonin or 5-hydroxytryptamine (5-HT) is a substance found in plasma, which increases smooth muscle contraction and mediates platelet aggregation. In addition, it is a monoamine neurotransmitter and is imp...
Corrigendum [0.03%]
勘误表
Published Erratum
Expert opinion on therapeutic patents. 2015;25(12):1495. DOI:10.1517/13543776.2015.1118590 2015
Novel N-pyrimidin-4-yl-3-amino-pyrrolo [3, 4-C] pyrazole derivatives as PKC kinase inhibitors: a patent evaluation of US2015099743 (A1) [0.03%]
作为PKC激酶抑制剂的新N-吡啶基-3-氨-吡咯并[3,4-c]吡唑衍生物：对US2015099743(A1)专利的评估
Joydip Das
Joydip Das
Introduction: Protein kinase Cβ (PKCβ) is a member of the PKC family of serine/threonine kinases that has been implicated in the pathophysiology of diabetic complications. Developing small molecule drugs targeting this ...
The triumph of chemically enhanced cellular reprogramming: a patent review [0.03%]
化学增强细胞重编程的胜利：专利回顾
Muhammad Ayaz Anwar,Songmee Kim,Sangdun Choi
Muhammad Ayaz Anwar
Introduction: The revolutionary discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka has exposed science to new horizons. However, genetic modifications render reprogrammed cells unstable; for that reaso...
Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934) [0.03%]
用于各种中枢神经系统疾病的奥沙西汀-1受体拮抗剂环戊烷、四氢呋喃和吡咯烷衍生物（WO2015/055994；WO2015/124932；WO2015/124934）
Christoph Boss,Catherine Roch
Christoph Boss
The three patent applications WO2015/055994, WO2015/124932 and WO2015/124934 from Takeda Pharmaceuticals describe antagonists for the orexin-1 receptor, based on saturated substituted five-membered carbo- or heterocycles. According to the p...
John Okombo,Kelly Chibale
John Okombo
Introduction: New antimalarials with novel modes of action are crucial in countering the challenge of emerging drug-resistant Plasmodium falciparum. Equally significant is the identification and characterization of the ta...
Sara Consalvi,Mariangela Biava,Giovanna Poce
Sara Consalvi
Introduction: The COX enzymes play a central role in the biosynthetic pathway of important biological mediators called prostanoids. Differences in regulation of gene expression, stability of transcripts and proteins deter...
Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition [0.03%]
WO2015042088A1的一种新型脲类TrkA抑制剂骨架的评估研究
Vadim Bernard-Gauthier,Ralf Schirrmacher
Vadim Bernard-Gauthier
Tropomyosin receptor kinases (TrkA/B/C) are involved in the development and maintenance of the nervous system. TrkA is a target for chronic pain treatment due to the central position of the nerve growth factor (NGF)/TrkA pathway in nocicept...
2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014) [0.03%]
2-吲哚酮抗肿瘤药物研究专利概览(2008-2014)
Alberto Leoni,Alessandra Locatelli,Rita Morigi et al.
Alberto Leoni et al.
Introduction: 2-Indolinone is a well-known aromatic heterocyclic organic compound. A lot of work has been done on this bicyclic structure by academic and company researchers to synthesize compounds directed to a plethora ...