Laura A Svetaz,Agustina Postigo,Estefanía Butassi et al.
Laura A Svetaz et al.
Introduction: Combination therapy has emerged as an approach to improve the efficacy of antifungal drugs. Its main objective is to achieve synergistic interaction with higher antifungal properties and lower toxic effects ...
Flavia Laffleur
Flavia Laffleur
Introduction: With the introduction of mucoadhesion in 1980, pharmaceutical researchers have gained interest in mucoadhesive compositions. This interest has led to the development of mucoadhesive drug delivery systems aim...
Analysis of anti-asthmatic drug patents published in China between 2004 and 2013 [0.03%]
2004—2013年我国哮喘类药物专利分析
Hua Xie,Huiyun Zhang,Ke Cao et al.
Hua Xie et al.
Introduction: We previously reported that 789 anti-allergic patents were granted in China between 1988 and 2008, but the number of patents seems to have grown much faster in China in recent years. Therefore, it is necessa...
Substituted indoles as HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent evaluation (WO2015044928) [0.03%]
一种HIV-1非核苷类逆转录酶抑制剂的专利评估报告（公开号：WO2015044928）
Xiao Li,Ping Gao,Peng Zhan et al.
Xiao Li et al.
The invention described in this patent (WO2015044928) is related to compounds based on the substituted indole scaffold, their synthetic process and application to inhibit HIV-1 replication as non-nucleoside reverse transcriptase inhibitors ...
Simonetta Papa,Ilaria Caron,Filippo Rossi et al.
Simonetta Papa et al.
Introduction: Microglia are highly dynamic immune cells that play a key role in the development, hemostasis and inflammatory response of the central nervous system. These cells could be a valid therapeutic target because ...
Marion Donnier-Maréchal,Sébastien Vidal
Marion Donnier-Maréchal
Introduction: Control of glycemia is crucial in the treatment of type 2 diabetes complications. Glycogen phosphorylase (GP) releases glucose from the liver into the blood stream. Design of potent GP inhibitors is a therap...
Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof [0.03%]
WO2014207069A1：多靶点Hedgehog通路抑制剂及其应用的评估研究
Fabrizio Manetti,Elena Petricci
Fabrizio Manetti
In recent years, the involvement of the Hedgehog (Hh) signaling pathway in various human diseases and dysfunctions has been clearly demonstrated. Smoothened (Smo), one of the upstream signal transducers, has been the most druggable target o...
Deepinder Singh Malik,Neeraj Mital,Gurpreet Kaur
Deepinder Singh Malik
Introduction: Topical administration is the favored route for local delivery of therapeutic agents due to its convenience and affordability. The specific challenge of designing a therapeutic system is to achieve an optima...
Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease [0.03%]
甘露糖衍生的FimH拮抗剂：一种有前景的治疗泌尿系统感染和克罗恩病的抗菌 virulence 策略
Laurel K Mydock-McGrane,Zachary T Cusumano,James W Janetka
Laurel K Mydock-McGrane
Introduction: Type 1 pili are utilized by Gram-negative bacteria to adhere to host tissue and thus are a key virulence factor in urinary tract infections (UTIs) and Crohn's disease (CD). This adhesion is mediated through ...
Iwao Ojima,Brendan Lichtenthal,Siyeon Lee et al.
Iwao Ojima et al.
Introduction: Paclitaxel and docetaxel were two epoch-making anticancer drugs and have been successfully used in chemotherapy for a variety of cancer types. In the year 2010, a new taxane, cabazitaxel, was approved by FDA...