Recent progress in the development of Toll-like receptor (TLR) antagonists [0.03%]
toll样受体(tlr)拮抗剂开发的最新进展
Mahesh Chandra Patra,Sangdun Choi
Mahesh Chandra Patra
Introduction: Pattern recognition receptors (PRRs) of the innate immune system mediate and control the activation and progression of adaptive immunity. Toll-like receptors (TLRs) are the most notable of the PRRs: they pla...
Alice Machado-Silva,Danielle Passos-Silva,Robson Augusto Santos et al.
Alice Machado-Silva et al.
Introduction: Angiotensin-(1-7) is a key component of the Renin-Angiotensin System, which can counter-regulate several deleterious effects caused by angiotensin II. Due to the potential for therapeutic use, several of its...
Chao Lin,Xiaoan Wen,Hongbin Sun
Chao Lin
Introduction: Oleanolic acid belongs to the pentacyclic triterpene family. In China, oleanolic acid has been used as an over the counter (OTC) hepatoprotective drug for decades. Oleanolic acid and its derivatives present ...
Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015) [0.03%]
脂肪酸结合蛋白(FABP)抑制剂专利回顾(2012-2015)
Yan-Ting Wang,Chang-Hong Liu,Hai-Liang Zhu
Yan-Ting Wang
Introduction: Obesity, diabetes, atherosclerosis, hypertension, dyslipidemia, and metabolic syndrome are synergistically operating diseases that endanger human health. Many studies provide evidence for excessive free fatt...
Ruo-Jun Man,Long-Wang Chen,Hai-Liang Zhu
Ruo-Jun Man
Introduction: Telomerase is a ribonucleoprotein that catalyses the addition of telomeric repeat sequences (having the sequence 5'-TTAGGG-3' in humans) to the ends of chromosomes. Telomerase activity is detected in most ty...
Novel compound, organic cation transporter 3 detection agent and organic cation transporter 3 activity inhibitor, WO2015002150 A1: a patent evaluation [0.03%]
一种新型化合物、有机阳离子转运体3检测剂及有机阳离子转运体3活性抑制剂及其专利分析WO2015002150A1
Tao Hu,Li Wang,Xiaolei Pan et al.
Tao Hu et al.
Increasing pharmacological studies have demonstrated that organic cation transporter 3 (OCT3) plays an important role in controlling the extracellular concentrations of released monoamine neurotransmitter, suggesting that OCT3 might be a pr...
Formulation and dosage of therapeutic nanosuspension for active targeting of docetaxel (WO 2014210485A1) [0.03%]
用于多西他赛主动靶向的治疗型纳米混悬制剂及其给药（专利申请号：WO 2014210485A1）
Deep Pooja,Hitesh Kulhari,David J Adams et al.
Deep Pooja et al.
Non-specificity and drug resistance are two major limitations of all chemotherapeutic agents. Ligand-conjugated nanomedicine is the most versatile approach for targeted cancer therapy. Attaching a targeting ligand to the nanoparticle surfac...
Lisa C du Toit,Yahya E Choonara,Pradeep Kumar et al.
Lisa C du Toit et al.
Introduction: Polymeric networks for controlled drug delivery possess wide pharmaceutical and biomedical applications. Areas covered: I...
Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015) [0.03%]
专利中的抗菌肽(AMPs)药物候选者（2003-2015）
Paulina Kosikowska,Adam Lesner
Paulina Kosikowska
Introduction: Antimicrobial peptides (AMPs) represent the large group of endogenous compounds widely distributed in nature. Due to their broad spectrum of antibiotic activity, as well as anti-inflammatory and immunomodula...
Matthieu Collin
Matthieu Collin
Introduction: Immune checkpoint inhibitors, like anti-PD-1/PD-L1 antibodies, are revolutionizing therapeutic concepts in the treatment of cancer. Said class of drugs will represent a multi-billion dollar market over the c...