Sphingosine kinase inhibitors: a review of patent literature (2006-2015) [0.03%]
鞘氨醇激酶抑制剂的专利文献回顾(2006-2015)
Kevin R Lynch,S Brandon Thorpe,Webster L Santos
Kevin R Lynch
Sphingosine kinase (SphK1 & SphK2) is the sole source of the pleiotropic lipid mediator, sphingosine-1-phosphate (S1P). S1P has been implicated in a variety of diseases such as cancer, Alzheimer's disease, sickle cell disease and fibrosis a...
HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015) [0.03%]
3-羟基-3甲基戊二酸单酰辅酶A还原酶抑制剂：2011-2015年新型化合物及药物制剂专利现状综述
Eduardo Filipe Oliveira,Diogo Santos-Martins,António Meireles Ribeiro et al.
Eduardo Filipe Oliveira et al.
Statins are remarkably safe and efficient medications that are the mainstay of hypercholesterolemia treatment and have proven to be an invaluable tool to lower the risk of acute cardiovascular events. These compounds are inhibitors of 3-hyd...
Novel pharmacological modulators of autophagy: an updated patent review (2012-2015) [0.03%]
自噬的新型药物调节剂：2012-2015年专利回顾
Joohun Ha,Joungmok Kim
Joohun Ha
Autophagy is a lysosome-dependent degradation pathway that maintains cellular homeostasis in response to a variety of cellular stresses. Accumulating reports based on animal models have indicated the importance of this catabolic program in ...
Inhibitors of the bone morphogenetic protein (BMP) signaling pathway: a patent review (2008-2015) [0.03%]
骨形态生成蛋白(BMP)信号途径抑制剂的专利回顾(2008-2015)
Corey R Hopkins
Corey R Hopkins
The bone morphogenetic protein (BMP) is a critical signaling pathway and plays a diverse role in embryonic pattern formation and is implicated in a variety of disease processes, including anemia, bone formation, atherosclerosis, skin diseas...
Stable isotope biomarker breath tests for human metabolic and infectious diseases: a review of recent patent literature [0.03%]
人类代谢和感染疾病的稳定同位素生物标志物呼吸试验近期专利文献综述
Graham S Timmins
Graham S Timmins
Stable isotope breath tests can rapidly and quantitatively report metabolic phenotypes and disease in both humans and microbes in situ. The labelled compound is administered and acted upon by human or microbial metabolism, producing a label...
Syed Mohammed Ali Hussaini
Syed Mohammed Ali Hussaini
Introduction: Quinoline is a versatile bicyclic heterocyclic scaffold with immense therapeutic potential. Some of the compounds containing quinoline nucleus are agents of choice for the treatment of various ailments, part...
Synthetic drugs for the treatment of vitiligo: a patent review (2010-2015) [0.03%]
白癜病治疗的合成药物专利综述（2010-2015）
Andreia Freire de Menezes,Saravanan Shanmugam,Isla Alcântara Gomes et al.
Andreia Freire de Menezes et al.
Vitiligo is one of the most important acquired depigmentation disorders, with an average worldwide prevalence of 0.5-2.0%. The exact etiology of vitiligo is not fully understood, but the principle theories focus on the mechanism responsible...
Christopher H George,Alice N Mitchell,Ryan Preece et al.
Christopher H George et al.
Introduction: The re-purposing of the anti-anginal drug perhexiline (PHX) has resulted in symptomatic improvements in heart failure (HF) patients. The inhibition of carnitine palmitoyltransferase-1 (CPT-1) has been propos...
Vitamin D receptor 2016: novel ligands and structural insights [0.03%]
2016年维甲酸核受体研究进展：新配体和结构洞察维生素D受体
Miguel A Maestro,Ferdinand Molnár,Antonio Mouriño et al.
Miguel A Maestro et al.
Vitamin D3 activates via its hormonal form 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), the transcription factor vitamin D receptor (VDR). VDR is expressed in most human tissues and has more than 1,000 target genes. Thus, 1α,25(OH)2D3 and i...
Anita Mandhare,Paromita Banerjee
Anita Mandhare
Colchicine, the major alkaloid extracted from the meadow saffron (Colchicum autumnale) is one of the most prominent natural products belonging to the class of organic compounds known as tropones. Colchicine's medicinal properties have been ...