Graça Soveral,Angela Casini
Graça Soveral
Since the discovery of aquaporin-1 (AQP1) as a water channel, more than 2,000 articles, reviews and chapters have been published. The wide tissue expression, functional and biological roles have documented the major and essential physiologi...
Medical countermeasures for unwanted CBRN exposures: part II radiological and nuclear threats with review of recent countermeasure patents [0.03%]
针对非期望的化学、生物、放射性和核威胁暴露的医学对策第二部分：放射和核威胁及近期对策专利综述
Vijay K Singh,Patricia L P Romaine,Victoria L Newman et al.
Vijay K Singh et al.
The global threat of a chemical, biological, radiological, or nuclear (CBRN) disaster is an important priority for all government agencies involved in domestic security and public health preparedness. Radiological/nuclear (RN) attacks or ac...
Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1) [0.03%]
用于神经退行性疾病诊断或治疗的转位蛋白(TSPO)配体专利回顾(2010-2015年 第一部分)
TaeHun Kim,Ae Nim Pae
TaeHun Kim
The translocator protein (TSPO) is an emerging target in diverse neurodegenerative diseases. Up-regulated TSPO in the central nervous system (CNS) appears to be involved in neuroinflammatory processes; therefore, the development of potent T...
Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review [0.03%]
p53/MDM2/MDM4线路中的肽和肽模拟物-专利综述
Emanuela Teveroni,Rossella Lucà,Marsha Pellegrino et al.
Emanuela Teveroni et al.
Restoration of the p53 tumor suppressor function is an attractive anticancer strategy. Despite the development of several therapeutics targeting the two main p53 negative regulators, MDM2 and MDM4, no one has yet reached clinical applicatio...
Medical countermeasures for unwanted CBRN exposures: Part I chemical and biological threats with review of recent countermeasure patents [0.03%]
针对非期望的化学、生物、放射性和核威胁暴露的医学补救措施第1部分：化学和生物威胁及近期补救专利回顾
Vijay K Singh,Melissa Garcia,Stephen Y Wise et al.
Vijay K Singh et al.
The threat of chemical, biological, radiological, and nuclear (CBRN) warfare has been addressed as the uppermost risk to national security since the terrorist attacks on 11 September 2001. Despite significant scientific advances over the pa...
Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2) [0.03%]
用于神经退行性疾病诊断或治疗的转位蛋白(TSPO)配体专利回顾(2010-2015年)(二)
TaeHun Kim,Ae Nim Pae
TaeHun Kim
The 18-kDa translocator protein (TSPO) has been highlighted as a potential drug target in diverse neurodegenerative diseases because the up-regulation of TSPO in the CNS is related to neuroinflammation. Diverse TSPO ligands are currently in...
CA IX stratification based on cancer treatment: a patent evaluation of US2016/0002350 [0.03%]
基于癌症治疗的CA IX分层：对US2016/0002350专利的评估
Claudiu T Supuran
Claudiu T Supuran
Carbonic anhydrase IX (CA IX) is an enzyme overexpressed in many hypoxic tumors as a consequence of hypoxia inducible factor 1α (HIF-1α) transcription factor cascade. CA IX is a highly active catalyst for the conversion of CO2 to bicarbon...
Adelaide Maria de Souza Antunes,Rafaela Di Sabato Guerrante,Jorge de Paula Costa Ávila et al.
Adelaide Maria de Souza Antunes et al.
Arterial hypertension affects over one billion people around the world, making the prevention and treatment of this disease vital. Despite the efforts made to develop new antihypertensive drugs, few new therapies have become available. Angi...
Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents [0.03%]
炎症介导的疾病的治疗靶点——细胞坏死性凋亡抑制剂——文献和专利综述
Spandana Rajendra Kopalli,Tae-Bong Kang,Sushruta Koppula
Spandana Rajendra Kopalli
Recent studies have shown substantial interplay between the apoptosis and necroptosis pathways. Necroptosis, a form of programmed cell death, has been found to stimulate the immune system contributing to the pathophysiology of several infla...
Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1 [0.03%]
美国专利US20150284376A1的矿皮质激素受体拮抗剂：专利点评
Matthieu Collin,Frédéric Jaisser
Matthieu Collin
Recent clinical studies showed that mineralocorticoid receptor antagonists are able to markedly reduce the overall and cardiovascular mortality in patients with left ventricular systolic dysfunction and mild or severe symptoms of chronic he...