New antimycobacterial agents in the pre-clinical phase or beyond: recent advances in patent literature (2001-2016) [0.03%]
专利文献中的抗分枝杆菌新药(2001-2016)
Patricia Bento da Silva,Débora Leite Campos,Camila Maríngolo Ribeiro et al.
Patricia Bento da Silva et al.
Tuberculosis, an infectious disease, has caused more deaths worldwide than any other single infectious disease, killing more than 1.5 million people each year; equating to 4,100 deaths a day. In the past 60 years, no new drugs have been add...
Boron's journey: advances in the study and application of pharmacokinetics [0.03%]
硼的旅程：药代动力学研究及应用进展
Ana L Ocampo-Néstor,José G Trujillo-Ferrara,Antonio Abad-García et al.
Ana L Ocampo-Néstor et al.
Boron-containing compounds (BCCs) are attractive chemical entities in drug development. Some of these compounds have been used in the treatment of human disease, and studies on their pharmacodynamics suggest that they employ multiple forms ...
Chiara Ruzza,Girolamo Calò,Salvatore Di Maro et al.
Chiara Ruzza et al.
Neuropeptide S (NPS) is a 20-residue peptide and endogenous ligand of the NPS receptor (NPSR). This receptor was a formerly orphan GPCR whose activation increases calcium and cyclic adenosine monophosphate levels. The NPS/NPSR system is exp...
2,2,2-Trifluoroethyl-thiadiazines: a patent evaluation of WO2016023927 [0.03%]
2,2,2-三氟乙基噻二嗪：WO2016023927专利评估报告
Victor V Dotsenko,Elena A Chigorina,Sergey G Krivokolysko
Victor V Dotsenko
The Alzheimer's disease (AD) is acknowledged as the most common type of dementia in aging adults. It is characterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid plaques. The latter insoluble deposits...
Anil Kumar,Dinesh K Dhull,Varun Gupta et al.
Anil Kumar et al.
Role of Glutathione-S-transferases (GSTs) has been well explored in the cellular detoxification process, regulation of redox homeostasis and S-glutothionylation of target proteins like JNK, ASK1 etc. However, altered levels or functions of ...
Oleanane derivatives for pharmaceutical use: a patent review (2000-2016) [0.03%]
橄榄烷衍生物的药物用途专利综述(2000-2016)
Milena Masullo,Cosimo Pizza,Sonia Piacente
Milena Masullo
Oleanolic acid has been considered a good start molecule for synthetic exploitation. Thus hundreds of oleanane triterpenoids have been synthesized and patented. Also many oleanane saponins have been patented for their biological activities ...
Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1 [0.03%]
JAK家族激酶抑制剂的专利文献(2013-2015)更新，第一部分
Jason G Kettle,Annika Åstrand,Matthew Catley et al.
Jason G Kettle et al.
Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2) that are critical in cytokine signalling and are strongly linked to both cancer and inflammatory diseases. There are currently two launched JAK...
Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2 [0.03%]
Janus激酶家族抑制剂的专利文献（2013-2015）第二部分更新
Jason G Kettle,Annika Åstrand,Matthew Catley et al.
Jason G Kettle et al.
Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2) that are critical in cytokine signalling and are strongly linked to both cancer and inflammatory diseases. There are currently two launched JAK...
Schiff bases in medicinal chemistry: a patent review (2010-2015) [0.03%]
Schiff碱在药物化学中的应用：2010-2015年专利回顾
Abdul Hameed,Mariya Al-Rashida,Maliha Uroos et al.
Abdul Hameed et al.
Schiff bases are synthetically accessible and structurally diverse compounds, typically obtained by facile condensation between an aldehyde, or a ketone with primary amines. Schiff bases contain an azomethine (-C = N-) linkage that stitches...
Lijia Chen,Steven Fletcher
Lijia Chen
The myeloid cell leukemia-1 (MCL-1) protein is one of the key anti-apoptotic members of the B-cell lymphoma-2 (BCL-2) protein family. Over-expression of MCL-1 has been closely related to tumor progression as well as to resistance, not only ...