Topoisomerase II inhibitors in oncology: an updated patent review (2016-present) [0.03%]
抗癌拓扑异构酶II抑制剂的专利回顾（2016-至今）
Eleonora Turrini,Francesca Maffei,Andrea Milelli et al.
Eleonora Turrini et al.
Introduction: Topoisomerase (topo) II inhibitors continue to represent a promising approach in anticancer therapy, although their clinical application is hampered by drug resistance and dose limiting toxicities. ...
Toll-like receptor agonists as cancer therapeutics: a patent review (2014-2024) [0.03%]
toll-like受体激动剂作为抗癌药物的专利回顾（2014-2024）
Pankaj Kumar,Zahid Bashir Zargar,Kanwaljit Chopra et al.
Pankaj Kumar et al.
Introduction: Toll-like receptors (TLRs) play key role in cancer immunotherapy by harnessing the immune system's natural response to target and fight tumors. Among various TLRs, mainly TLR3, TLR4, TLR7, TLR8, and TLR9, ha...
Bruton's tyrosine kinase (BTK) inhibitors: an updated patent review (2019-2024) [0.03%]
布鲁顿酪氨酸激酶(BTK)抑制剂专利回顾(2019-2024)更新版
Ze-Xi Cui,Sheng-Xin Yao,Yue-Xi Zhang et al.
Ze-Xi Cui et al.
Introduction: Bruton's tyrosine kinase (BTK) is a critical regulator in the pathogenesis of B-cell malignancies, inflammatory diseases, and autoimmune diseases. In recent years, BTK inhibitors have been a hot topic in dru...
Implementation and outcomes of China's drug patent linkage system: lessons from international experience [0.03%]
中国药品专利链接制度的实施及成效：国际经验借鉴
Yu Chen,Xinjuan Liu,Suju Li et al.
Yu Chen et al.
Introduction: The drug patent linkage system plays a crucial role in achieving a balance between protecting drug innovation and ensuring the accessibility of generic drugs. Currently, this system has been implemented in m...
Evaluation of the patent portfolio for helicase-primase inhibitor ABI-5366 of Assembly biosciences inc [0.03%]
评估Assembly Biosciences Inc.的HELQ抑制剂ABI-5366专利组合
Christian Gege,Gerald Kleymann
Christian Gege
Background: Helicase-primase is an interesting target for small molecule therapy of herpes simplex virus (HSV) infections. With amenamevir already approved for varicella-zoster virus and herpes simplex in Japan and with p...
Tao Liu,Mingbo Su,Yuxuan Wang et al.
Tao Liu et al.
Introduction: Checkpoint kinase 1 (CHK1), a serine/threonine kinase, plays an important role in the DNA damage response (DDR), such as cell cycle checkpoints, DNA repair, transcriptional regulation, and apoptosis inhibiti...
Traf2- and Nck-interacting kinase inhibitors: a patent review（2008 - 2024） [0.03%]
有关Traf2和Nck相互作用激酶的抑制剂专利综述（2008-2024）
Luoheng Qin,Vladimir Aladinskiy,David Gennert et al.
Luoheng Qin et al.
Introduction: Traf2- and Nck-interacting kinase (TNIK) is a crucial player in various intracellular signaling pathways, including Wnt/β-catenin, cytoskeleton organization, and immune activation. It phosphorylates several...
An updated patent review on rational combinations of HDAC inhibitors for cancer chemotherapy (2020 - present): part 1-patent granted [0.03%]
组蛋白去乙酰化酶抑制剂合理联用治疗癌症的专利点评（2020-至今）：已授权部分
Yugal Kishor Shukla,Vandana,Vivekananda Mandal et al.
Yugal Kishor Shukla et al.
Introduction: Tumor cell heterogeneity poses a challenge to monotherapy, as a single drug cannot kill all heterogeneous cancer cells of a tumor. The surviving cells may develop resistance, potentially leading to tumor rec...
GPR120 agonists for the treatment of type 2 diabetes: an updated patent review (2020-present) [0.03%]
用于治疗2型糖尿病的GPR120激动剂专利回顾（2020-至今）
Kainat Ilyas,Ismat Nawaz,Kanwal Rehman et al.
Kainat Ilyas et al.
Introduction: Type 2 diabetes mellitus (T2DM) affects over 530 million individuals globally and is projected to reach 783 million by 2045, necessitating novel therapeutic strategies beyond current options. G-protein-coupl...
The potential of bacteriophages in treating multidrug-resistant ESKAPE pathogen infections [0.03%]
噬菌体在治疗耐多药ESKAPE病原感染方面的潜力
Izadora Dillis Faccin,Gleyce Hellen de Almeida de Souza,Jean Carlos Pael Vicente et al.
Izadora Dillis Faccin et al.
Introduction: Antimicrobial resistance (AMR) and the emergence of multidrug-resistant bacteria, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa...