Lapachol and lapachone analogs: a journey of two decades of patent research(1997-2016) [0.03%]
拉帕乔林和拉帕乔醇类似物的二十年专利研究历程（1997-2016）
Hidayat Hussain,Ivan R Green
Hidayat Hussain
Lapachol (1), β-lapachone (2) and α-lapachone (3) are three well-studied natural products isolated from Tabebuia impetiginosa having most interesting chemodiversity and demonstrating diverse biological effects. Areas covered: The current ...
Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) [0.03%]
乙酰胆碱酯酶复能剂及有机磷中毒治疗领域的进展：专利回顾（2006-2016）
Lukas Gorecki,Jan Korabecny,Kamil Musilek et al.
Lukas Gorecki et al.
organophosphorus compounds act as irreversible inhibitors of the vital enzyme acetylcholinesterase (AChE). this leads in the accumulation of acetylcholine (ACh) leading to cholinergic crisis and death. The main therapeutic approach is based...
Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015) [0.03%]
癌症干细胞(CSC)抑制剂近期专利(2012-2015)综述
Prashant S Kharkar
Prashant S Kharkar
Cancer stem cells (CSCs) mediate tumor initiation and maintenance. These cells are chemoresistant and possess characteristics such as self-renewal, pluripotency, plasticity and differentiation. They have aberrant or altered signaling pathwa...
Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016) [0.03%]
近期小分子Nrf2调节剂的研发进展：专利综述(2012-2016)
Haopeng Sun,Jie Zhu,Hongzhi Lin et al.
Haopeng Sun et al.
The NF-E2-related factor-2 (Nrf2) is a critical transcription factor that regulates the expression of many phase II and antioxidant genes to maintain the homeostasis. It has many biological functions and plays a central role in the cellular...
Evaluation of US 2016/0115161 A1: isoindoline compounds and methods of their use [0.03%]
评估美国专利申请US 2016/0115161 A1：异靛蓝化合物及其用途的方法
Rok Frlan,Stanislav Gobec
Rok Frlan
Immunomodulatory drugs (IMIDs®) are small orally available molecules that modulate the immune system and other biological targets through multiple mechanisms of action and have been successfully used in the treatment of myelodysplastic syn...
Aikaterini Nikolaou,Maroula G Kokotou,Dimitris Limnios et al.
Aikaterini Nikolaou et al.
Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to lysophosphatidic acid (LPA) and choline. The ATX/LPA axis has received increasing interest in recent years because both the enzyme ATX and the bioactive lipid L...
Wei-Wei Ni,Meng-Da Cao,Wen Huang et al.
Wei-Wei Ni et al.
Tryptase is one of the main serine-proteinases located in the secretory granules of mast cells, and is released through degranulation, which is involved in the pathogenesis of allergic inflammatory disease, cardiovascular diseases, lung fib...
Giulia Stazi,Clemens Zwergel,Antonello Mai et al.
Giulia Stazi et al.
The histone methyltransferase EZH2 is the catalytic subunit of the PRC2 complex involved in H3K27 trimethylation. Aberrant PRC2 activity has been reported in several cancers and EZH2 overexpression has been associated with poor outcome in d...
Methods of selecting combination therapy for colorectal cancer patients: a patent evaluation of US20160025730A1 [0.03%]
用于结直肠癌患者的联合治疗选择方法：对US20160025730A1专利的评估
Daniel Plano,Verónica Alcolea,Carmen Sanmartín et al.
Daniel Plano et al.
Colorectal cancer (CRC) is the fourth most common cancer worldwide. Targeted therapy drugs (TTDs) are a valid treatment, epithelial growth factor receptor (EGFR) inhibitors being one of the most commonly used for CRC patients. However, this...
Bhuvaneshwar Vaidya,Matthew Pangallo,Gregoire Ruffenach et al.
Bhuvaneshwar Vaidya et al.
Current therapeutic approaches for pulmonary arterial hypertension (PAH) commonly include use of prostacyclins, endothelin pathway antagonists or NO (nitric oxide) pathway modulators. These agents are non-specific and suffer from several im...