Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells US2015011543 (a1): a patent evaluation [0.03%]
用于扩展造血干细胞的嘧啶并吲哚衍生物及其用途美国专利US2015011543A1：评估报告
Stuti Agarwal,Hitesh Agarwal,Nilesh Zaware
Stuti Agarwal
There is an unmet need of strategies for ex-vivo expansion of hematopoetic stem cells (HSCs) without loss of their primitive nature or stemness. We evaluate here a patent that attempts to address this need via key small molecules 1 and 40 t...
Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1 [0.03%]
一类新的HIV-1整合酶抑制剂——螺环或取代的喹唑啉衍生物：对WO2016094197A1、WO2016094198A1和WO2016154527A1专利申请的分析与评价
Xiqiang Cheng,Ping Gao,Lin Sun et al.
Xiqiang Cheng et al.
Highly active antiretroviral therapy (HAART) has been widely adopted to control the HIV-1 infection successfully. HIV-1 integrase (IN) inhibitors are primary drugs in HAART regimens targeting integration step in the HIV-1 life cycle. Howeve...
Dmitrii V Kalinin,Ralph Holl
Dmitrii V Kalinin
The Zn2+-dependent deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising target for the development of antibiotics selectively combating Gram-negative pathogens. Researchers from industry ...
Francesca Musumeci,Monica Sanna,Chiara Greco et al.
Francesca Musumeci et al.
Btk is a tyrosine kinase dysregulated in several B-cell malignancies and autoimmune diseases, and this has given rise to a search for Btk inhibitors. Nevertheless, only one Btk inhibitor, ibrutinib, has been approved to date, although other...
Saffron and its derivatives, crocin, crocetin and safranal: a patent review [0.03%]
藏红花及其衍生物藏红花素、藏红花酸和藏红花醛的专利回顾
Maryam Rameshrad,Bibi Marjan Razavi,Hossein Hosseinzadeh
Maryam Rameshrad
Introduction: Saffron and its main components have traditionally been used as pharmaceutical agents. Current experimental research projects have also exhibited their applications in a wide spectrum of disorder treatments....
Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review [0.03%]
脯氨酰氨基肽酶（PrCP）抑制剂及其治疗应用：专利综述
Thomas H Graham
Thomas H Graham
Prolylcarboxypeptidase (PrCP) is a serine protease that produces or degrades signaling proteins in several important pathways including the renin-angiotensin system (RAS), kallikrein-kinin system (KKS) and pro-opiomelanocortin (POMC) system...
Abdul Hameed,Mariya Al-Rashida,Rima D Alharthy et al.
Abdul Hameed et al.
From therapeutic point of view, it is often beneficial to enhance the expression of certain enzymes whose low expression is responsible for the observed ailment. Small molecules as activators of several enzymes have great biological potenti...
Between pharmaceutical patents and European patients: is a compromise still possible? [0.03%]
医药专利与欧洲患者：妥协的空间还有没有？
Livio Garattini,Anna Padula
Livio Garattini
Pharmaceutical regulation has always attempted to balance the public health objective to make safe and effective drugs available for patients while providing commercial incentives through patents. Here we discuss whether it is still possibl...
What's new in treatment of pancreatic cancer: a patent review (2010-2017) [0.03%]
近年胰腺癌治疗的新进展及其专利分析(2010-2017)
Maria C Ramos,Houria Boulaiz,Carmen Griñan-Lison et al.
Maria C Ramos et al.
Pancreatic cancer (PC) is one of the most lethal cancers, with a median overall survival of less than 1 year and a 5-year survival of ~5%. The poor survival rate is likely due to lack of early diagnosis, fast disease course, high metastasis...
New drugs or alternative therapy to blurring the symptoms of fibromyalgia-a patent review [0.03%]
新的药物或替代疗法用于改善纤维肌痛综合征-专利评论
Marlange A Oliveira,Adriana G Guimarães,Adriano A S Araújo et al.
Marlange A Oliveira et al.
Fibromyalgia (FM) is a musculoskeletal condition characterized by chronic widespread pain, tenderness and often accompanied by other comorbid conditions such as depression, anxiety, chronic fatigue, among others. Now, we aimed to survey the...