Cyclodextrins improving the physicochemical and pharmacological properties of antidepressant drugs: a patent review [0.03%]
环糊精改善抗抑郁药物的理化和药理性质：专利回顾
Tâmara Coimbra Diniz,Tiago Coimbra Costa Pinto,Paula Dos Passos Menezes et al.
Tâmara Coimbra Diniz et al.
Introduction: Depression is a serious mood disorder and is one of the most common mental illnesses. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to ...
What's new in the diagnosis of pancreatic cancer: a patent review (2011-present) [0.03%]
近年胰腺癌诊断的新进展：专利回顾（2011-至今）
Houria Boulaiz,María C Ramos,Carmen Griñán-Lisón et al.
Houria Boulaiz et al.
Pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the US with a 5-year survival rate of about 5%. Most patients have advanced metastatic disease mainly due to the lack of an effective early detection, and an extr...
Timothy A Katte,Michael Kassiou
Timothy A Katte
Trevor M Penning
Trevor M Penning
AKR1C3 is a drug target in hormonal and hormonal independent malignancies and acts as a major peripheral 17β-hydroxysteroid dehydrogenase to yield the potent androgens testosterone and dihydrotestosterone, and as a prostaglandin (PG) F syn...
Global patent landscape of programmed cell death 1: implications of the rapid expansion [0.03%]
程序性细胞死亡1的全球专利布局：快速增长的启示
Xiangjun Kong,Qianru Zhang,Yunfeng Lai et al.
Xiangjun Kong et al.
Introduction: Inhibitors of programmed cell death 1 (PD-1) and its ligands are producing a paradigm shift in cancer treatment. The promising clinical outcomes and a multi-billion dollar market have prompted active researc...
Caspase inhibitors: a review of recently patented compounds (2013-2015) [0.03%]
卡酶抑制剂研究进展：近五年专利回顾(2013-2015)
Hyemin Lee,Eun Ah Shin,Jae Hee Lee et al.
Hyemin Lee et al.
Introduction: Although many caspase inhibitors have been patented, caspase inhibitors have not entered the market due to their toxicity and poor pharmacokinetic profile. ...
Graham S Timmins
Graham S Timmins
The pharmacokinetics and/or toxicity of many known drugs can be modified by selective deuteration, an area of significant commercial interest and scientific and regulatory progress. Areas covered: This review firstly discusses recent develo...
Mariya Al-Rashida,Syeda Uroos Qazi,Nayab Batool et al.
Mariya Al-Rashida et al.
Ectonucleotidases are a broad family of metallo-ectoenzymes that are responsible for hydrolysing a variety of nucleotides to nucleosides, hence orchestrating the activation of P1 and P2 cell receptors via controlled release of nucleotides a...
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature [0.03%]
二氢生物碱调节激酶1A(DYRK1A)抑制剂近期专利文献综述
Thu Lan Nguyen,Corinne Fruit,Yann Hérault et al.
Thu Lan Nguyen et al.
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a eukaryotic serine-threonine protein kinase belonging to the CMGC group. DYRK1A hyperactivity appears to contribute to the development of a number of human malignanc...
Anastasia Detsi,Christos Kontogiorgis,Dimitra Hadjipavlou-Litina
Anastasia Detsi
Introduction: Coumarins belong to the benzopyrone family. They are naturally plant-derived or synthetically obtained substances, presenting a wide variety of biological activities, offering an extented therapeutic profile...