Bicyclic bis-heteroaryl derivatives as inhibitors of the α-synuclein protein: a patent evaluation of WO2018138088A1 [0.03%]
二环双杂芳基衍生物作为α-突触核蛋白抑制剂的专利分析：WO2018138088A1
Jacques Joubert
Jacques Joubert
Introduction: Neurodegenerative diseases commonly present misfolding and aggregation of one or more proteins, including α-synuclein, β-amyloid, and tau. Several research efforts have been made to develop therapeutic agents able to reduce ...
Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review [0.03%]
人工合成的 toll 样受体激动剂开发高效疟疾疫苗：专利分析
Arshpreet Kaur,Deepika Kannan,Surinder K Mehta et al.
Arshpreet Kaur et al.
Introduction: Currently, there is no efficient vaccine available against clinical malaria. However, continuous efforts have been committed to develop powerful antimalarial vaccine by discovery of novel antigens with in-de...
Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018) [0.03%]
心脏疾病治疗中氯马斯特抑制剂的研究进展(2010-2018)
Sarfaraz Ahmad,Carlos M Ferrario
Sarfaraz Ahmad
Introduction: Chymase is primarily found in mast cells (MCs), fibroblasts, and vascular endothelial cells. MC chymase is released into the extracellular interstitium in response to inflammatory signals, tissue injury, and...
CanRong Wu,LiXia Chen,Sanshan Jin et al.
CanRong Wu et al.
Introduction: The kidney-type glutaminase (GLS) controlling the first step of glutamine metabolism is overexpressed in many cancer cells. Targeting inhibition of GLS shows obvious inhibitory effects on cancer cell prolife...
Hong Wang,Qingxian He,Guangji Wang et al.
Hong Wang et al.
Introduction: Farnesoid X receptor (FXR), a nuclear receptor mainly expressed in enterohepatic tissues, is a master for bile acid, lipid and glucose homeostasis. Additionally, it acts as a cell protector with unclear mech...
Novel platinum agents and mesenchymal stromal cells for thoracic malignancies: state of the art and future perspectives [0.03%]
新型铂类药物和间充质基质细胞在胸部恶性肿瘤中的应用：现状与未来展望
Francesco Petrella,Isabella Rimoldi,Giorgio Facchetti et al.
Francesco Petrella et al.
Introduction: Non-small cell lung cancer and malignant pleural mesothelioma represent two of the most intriguing and scrutinized thoracic malignancies, presenting interesting perspectives of experimental development and c...
Therapeutic potential of oxazole scaffold: a patent review (2006-2017) [0.03%]
噁唑类药物的治疗潜力：专利回顾(2006-2017)
Ramandeep Kaur,Kezia Palta,Manoj Kumar et al.
Ramandeep Kaur et al.
Introduction: Oxazoles are oxygen and nitrogen containing five membered heterocyclic ring systems that are present in various anticancer, antimicrobial, antihyperglycemic, anti-inflammatory agents etc. of natural origin. ...
Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas [0.03%]
碳酸酐酶抑制剂及其在多种治疗领域中的潜力
Claudiu T Supuran
Claudiu T Supuran
The sigma-2 (σ-2) receptor: a review of recent patent applications: 2013-2018 [0.03%]
σ-2受体的专利申请概览（2013-2018）
Benjamin E Blass,John Patrick Rogers
Benjamin E Blass
Introduction: The discovery of the sigma-2 receptor and the analogous sigma-1 receptor led to a decade-long quest to determine the true nature of this protein and novel ligands capable of modulating its activity. Despite ...
Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases [0.03%]
碳酸酐酶抑制剂在肾病和中枢神经系统疾病中的应用
Claudiu T Supuran
Claudiu T Supuran
Introduction: There are tissues and organs, among which kidneys and the central nervous system (CNS), rich in various isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). Their role is to regulate pH, to pro...