Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review [0.03%]
色氨酸2,3-双氧化酶抑制剂的最新研究进展：专利分析
Arina Kozlova,Raphaël Frédérick
Arina Kozlova
Introduction: Tryptophan-2, 3-dioxygenase (TDO2) is a tryptophan-degrading enzyme constitutively expressed in the liver and to a lesser extend in the brain. Before its link to cancer immunotherapy was discovered in 2011, ...
Therapeutic potential of Panax ginseng and its constituents, ginsenosides and gintonin, in neurological and neurodegenerative disorders: a patent review [0.03%]
人参及其成分(ginsenoside和gintonin)在神经和神经退行性疾病方面的治疗潜力：专利回顾
Arezoo Rajabian,Maryam Rameshrad,Hossein Hosseinzadeh
Arezoo Rajabian
Introduction: Ginseng, Panax ginseng, has been used for various diseases and proven its great efficacy in managing central nervous system diseases. Areas ...
Patricia Daliu,Antonello Santini,Ettore Novellino
Patricia Daliu
In the last 10 years, nutraceuticals have grown in interest to researchers, industry, and consumers and are now familiar in the collective imagination as a tool for preventing the onset of a disease. Often nutraceuticals are confused with b...
Hippo pathway inhibition by blocking the YAP/TAZ-TEAD interface: a patent review [0.03%]
靶向YAP/TAZ-TEAD相互作用治疗组蛋白甲基转移酶抑制剂耐药的 hippo 通路专利综述
James J Crawford,Sarah M Bronner,Jason R Zbieg
James J Crawford
Introduction: The Hippo pathway represents a new and intriguing opportunity for the treatment of cancer. Activation or overexpression of Yes-associated protein (YAP) or transcriptional coactivator with PDZ-binding motif (TAZ) has been shown...
Qing-Wen Zhang,Zi-Dan Ye,Lei Shi
Qing-Wen Zhang
Introduction: The receptor tyrosine kinase c-Met is involved in the formation, metastasis and invasion of various malignant tumors thus it has been an attractive target for anti-tumor drug designing. Many compositions tar...
Xin Li,Ekinci Elmira,Sagar Rohondia et al.
Xin Li et al.
Ubiquitin-proteasome system (UPS) has been validated as a novel anticancer drug target in the past 20 years. The UPS contains two distinct steps: ubiquitination of a substrate protein by ubiquitin activating enzyme (E1), ubiquitin conjugati...
Hao Li,Shi-Ying Huang,Fang-Hong Shi et al.
Hao Li et al.
The α4β7 integrin is heterodimeric cell surface receptors expressed on most leukocytes. Mucosal addressing cell adhesion molecule 1(MAdCAM-1) is an exclusive ligand for α4β7 integrin. Areas covered: This article will highlight the progr...
Evaluation of WO2014121383 A1: a process for preparation of rufinamide and intermediates [0.03%]
WO2014121383A1鲁拉西酮的制备方法及其中间体的评估研究
Barnali Maiti,Balamurali M M,Kaushik Chanda
Barnali Maiti
There is great potential in the synthetic development of rufinamide to treat childhood-onset epilepsy known as Lennox-Gastaut syndrome (LGS). Areas covered: 1,4-disubstituted triazole ring formed by 1,3-dipolar cycloaddition reaction is an ...
Ghilsoo Nam
Ghilsoo Nam
Introduction: T-type calcium channels are attractive targets for potential treatment of epilepsy inflammatory or neuropathic pain, insomnia, Parkinson's disease, and cancer. Three isoforms having different biophysical fun...
Xin Chen,Likun Zhang,Mingxiang Zhang et al.
Xin Chen et al.
Introduction: Quorum sensing (QS) is a cell density-dependent phenomenon in which specific pathways are activated after autoinducers (AIs) outside the microorganism reach a threshold concentration. QS creates a positive feedback loop that i...