Patent landscape for discovery of promising acyltransferase DGAT and MGAT inhibitors [0.03%]
酰基转移酶DGAT和MGAT抑制剂的专利布局分析
Vishal P Zambre,Shamali M Khamkar,Dnyaneshwar D Gavhane et al.
Vishal P Zambre et al.
Introduction: DGAT and MGAT enzymes play an important role in triacylglycerol (TGA) biosynthesis. Overexpression of these enzymes may lead to accumulation of TGA in adipose tissues causing development of diseases such as ...
Repositioning and investigational drugs for Zika virus infection treatment: a patent review [0.03%]
兹卡病毒感染治疗的重新定位和研究药物：一项专利回顾
Sandro G Viveiros Rosa,Iolanda M Fierro,Wilson C Santos
Sandro G Viveiros Rosa
Introduction: Zika virus (ZIKV) is transmitted to humans throughout bites of Aedes mosquitoes. ZIKV infection may be asymptomatic in most cases, but it may cause fever, headache, muscle pain, and rash. Guillain-Barré syn...
Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2016-2019) [0.03%]
甘油合成酶激酶3(GSK-3)抑制剂：专利更新(2016-2019)
Carlos Roca,Nuria E Campillo
Carlos Roca
Introduction: Glycogen synthase kinase 3 (GSK-3) is a constitutively active, ubiquitous expressed ser/thr kinase that is involved in a large number of signaling pathways. GSK-3 is a key target of a remarkably large number...
Antibacterial carbonic anhydrase inhibitors: an update on the recent literature [0.03%]
抗菌碳酸酐酶抑制剂：最新文献综述
Claudiu T Supuran,Clemente Capasso
Claudiu T Supuran
Introduction: The clinically licensed drugs used as antibiotics prevent the microbial growth interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis or wall permeability, and microbia...
GPR120 agonists for the treatment of diabetes: a patent review (2014 present) [0.03%]
GPR120激动剂在糖尿病治疗中的应用：专利回顾（2014年至今）
Xuqing Zhang,Mark J Macielag
Xuqing Zhang
Introduction: G protein-coupled receptor 120 (GPR120) is a Gαq coupled GPCR specifically activated by long-chain fatty acids (LCFAs). Functionally, it has been identified as a member of a family of lipid-binding free fat...
GLP-1R agonists for the treatment of obesity: a patent review (2015-present) [0.03%]
GLP-1R激动剂在治疗肥胖中的应用：专利综述（2015年至今）
Chunxia Liu,Yuxing Zou,Hai Qian
Chunxia Liu
Introduction: Glucagon-like peptide-1 (GLP-1) is an endogenous peptide which is secreted by enteroendocrine L cells, GLP-1 receptor agonists (GLP-1 RAs) can exhibit glucoregulation by stimulating insulin release, promote ...
Xanthine oxidase inhibitors: patent landscape and clinical development (2015-2020) [0.03%]
黄嘌呤氧化酶抑制剂：专利格局和临床开发（2015-2020）
Jatinder Vir Singh,Preet Mohinder Singh Bedi,Harbinder Singh et al.
Jatinder Vir Singh et al.
Introduction: Xanthine oxidase (XO) is a molybdoflavoprotein that catalyzes the oxidative hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction products can cause severe disease conditi...
Bispecific anti-PD-L1/PD-1 antibodies for advanced solid tumors: a patent evaluation of US2019010232 [0.03%]
抗PD-L1/PD-1双特异性抗体治疗晚期实体瘤：对专利US2019010232的评估
Nemesio Villa-Ruano,Tayde Guerrero-González,Eduardo Gómez-Conde et al.
Nemesio Villa-Ruano et al.
Introduction: PD-L1 and PD-1 are two immune checkpoints and their presence in various types of tumors is related to a poor prognosis; this makes them highly relevant targets in the development of new therapies. Patent US2...
Discovery and optimizing polycyclic pyridone compounds as anti-HBV agents [0.03%]
多环吡啶酮类化合物作为抗乙肝病毒药物的发现与优化研究
Fenju Wei,Dongwei Kang,Srinivasulu Cherukupalli et al.
Fenju Wei et al.
Introduction: Hepatitis B disease is caused by the hepatitis B virus (HBV), which is a DNA virus that belongs to the Hepadnaviridae family. It is a considerable health burden, with 257 million active cases globally. Long-...
Small molecules as antagonists of co-inhibitory pathways for cancer immunotherapy: a patent review (2018-2019) [0.03%]
用于抗癌免疫治疗的共抑制通路小分子拮抗剂专利回顾（2018-2019）
Qiaohong Geng,Sagar O Rohondia,Harras J Khan et al.
Qiaohong Geng et al.
Introduction: Therapeutic antibodies blocking co-inhibitory pathways do not attack tumor cells directly, but instead bind to their targeted proteins and mobilize the immune system to eradicate tumors. However, only a smal...