Zehui Tan,Hongrui Lei,Ming Guo et al.
Zehui Tan et al.
Introduction: The ATX-LPA axis is an attractive target for therapeutic intervention in a variety of diseases, such as tumor metastasis, fibrosis, pruritus, multiple sclerosis, inflammation, autoimmune conditions, metaboli...
Monocyclic beta-lactams for therapeutic uses: a patent overview (2010-2020) [0.03%]
用于药物的单环β-内酰胺专利概览(2010-2020)
Katarina Grabrijan,Nika Strašek,Stanislav Gobec
Katarina Grabrijan
Introduction: Monocyclic beta-lactams are four-membered cyclic amides with various structural modifications of the nucleus that determine their chemical reactivity and target specificity. Their historical use is based on ...
Recent progress in the development of β2 adrenergic receptor agonists: a patent review (2015-2020) [0.03%]
近期β2肾上腺素受体激动剂研发进展（2015-2020）专利回顾
Gang Xing,Ce Yi,Peiyuan Dou et al.
Gang Xing et al.
Introduction: The β2 adrenergic receptor (β2AR) is a member of G protein-coupled receptors (GPCRs) that mediate the majority of cellular responses to external stimuli. The agonists can cause smooth muscle relaxation; th...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: a patent review (2014-present) [0.03%]
表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌治疗中的应用：专利回顾（2014-至今）
Xin Sun,Shan Xu,Zunhua Yang et al.
Xin Sun et al.
Introduction: EGFR is the receptor for epidermal growth factor (EGF) and belongs to the protein tyrosine kinase (PTK) receptor. It is closely related to the inhibition of tumor cell proliferation, invasion, and apoptosis. Overexpression or ...
Jacopo Cusinato,Ylenia Cau,Anna Maria Calvani et al.
Jacopo Cusinato et al.
Introduction: The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 represents a serious health issue worldwide, with more than 61 million cases and more than 1.4 million deaths since the beginning of the epidemic near the end of 201...
Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020) [0.03%]
药物化学中的多组分反应(MCR)：一项专利回顾(2010-2020)
Hafiza Amna Younus,Mariya Al-Rashida,Abdul Hameed et al.
Hafiza Amna Younus et al.
Introduction: Multicomponent reactions (MCR) has been utilized to synthesize a vast range of analogs belonging to diverse classes of heterocyclic compounds offering multidimensional pharmaceutical applications. The unique feature of MCR inc...
Philip A Harris
Philip A Harris
Introduction: RIP1 kinase is a serine/threonine-protein kinase that has recently emerged as a central regulator of TNF-α dependent programmed necrosis (necroptosis), an inflammatory form of cell death, with important roles in inflammation ...
Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [0.03%]
针对冠状病毒主要蛋白酶和半胱天冬酶样蛋白酶的蛋白酶抑制剂
Clemente Capasso,Alessio Nocentini,Claudiu T Supuran
Clemente Capasso
Introduction: The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved a...
Paolo Guglielmi,Virginia Pontecorvi,Giulia Rotondi
Paolo Guglielmi
Introduction: Antimicrobial resistance is a worldwide problem accounting for the reduction or in some cases absence of drugs effectiveness normally used in infections treatment. In the light of the even more spread ability of microbials to ...
Giannamaria Annunziato,Gabriele Costantino
Giannamaria Annunziato
Introduction: Antimicrobial peptides are a large class of compounds that are part of innate immune response found among all classes of life and are considered promising compounds to deal with antimicrobial resistance. These AMPs have been d...