Hanan S Anbar,Zahraa Isa,Jana J Elounais et al.
Hanan S Anbar et al.
Introduction: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive sulfate metabolites of steroid sex hormones into the active free steroids. Both the deficiency and the over-expression of STS are associated with the ...
An updated patent review of galectin-1 and galectin-3 inhibitors and their potential therapeutic applications (2016-present) [0.03%]
2016年至今半乳糖凝集素-1和半乳糖凝集素-3抑制剂的专利综述及其潜在治疗应用
Aaftaab Sethi,Swetha Sanam,Ravi Alvala et al.
Aaftaab Sethi et al.
Introduction: Galectins are ubiquitous in nature. They have established themselves as a protein family of high therapeutic potential and play a role in a wide variety of diseases like cancer, fibrosis, and Alzheimer's. Wi...
Recent progress in small molecule TBK1 inhibitors: a patent review (2015- 2020) [0.03%]
2015—2020年TBK1小分子抑制剂研究进展及相关专利分析
Douglas W Thomson,Giovanna Bergamini
Douglas W Thomson
Introduction: TANK-binding kinase 1 (TBK1) is a key mediator of innate immunity processes and studies have reported on its role in inflammatory and autoimmune diseases. Moreover, several studies have also described the important role of TBK...
Brian G Lawhorn,Edward J Brnardic,David J Behm
Brian G Lawhorn
Introduction: Transient receptor potential vanilloid 4 (TRPV4) is an ion channel that is widely expressed and is activated by numerous chemical, osmotic and mechanical stimuli. By modulating Ca2+ entry, TRPV4 regulates cellular signaling as...
Negative allosteric modulators of group II metabotropic glutamate receptors: A patent review (2015 - present) [0.03%]
格鲁比代谢型谷氨酸受体的负变构调节剂专利回顾（2015-至今）
Alshaima&#x;a M Qunies,Kyle A Emmitte
Alshaima&#x;a M Qunies
Introduction: Group II metabotropic glutamate (mGlu) receptors have emerged as an attractive potential target for the development of novel CNS therapeutics in areas such as Alzheimer's disease (AD), anxiety, cognitive dis...
Visible light-curable water-soluble chitosan derivative, chitosan hydrogel, and preparation method: a patent evaluation of US2019202998A1 [0.03%]
一种可见光固化的水溶性壳聚糖衍生物、壳聚糖水凝胶及其制备方法：对US2019202998A1的专利评价
Thashree Marimuthu,Pradeep Kumar,Yahya E Choonara
Thashree Marimuthu
Introduction: Water soluble polysaccharides are versatile structural materials that can be used for the design of biocompatible hydrogels and wet dressings in wound healing applications. Glycol chitosan (GC) is an example of a multifunction...
Mohd Imran,Alshrari A S,Hamdy Kh Thabet et al.
Mohd Imran et al.
Introduction: In recent years, the advent of multidrug-resistant tuberculosis (MDR-TB), the extensively-resistant TB (XDR-TB), and the total drug-resistant-TB (TDR-TB) have led the community to develop new antitubercular ...
Coronaviruses [0.03%]
冠状病毒屬
Claudiu T Supuran
Claudiu T Supuran
Thioredoxin reductase inhibitors: updated patent review (2017-present) [0.03%]
硫氧还蛋白还原酶抑制剂专利回顾（2017-至今）
Evgeny Chupakhin,Mikhail Krasavin
Evgeny Chupakhin
Introduction: Thioredoxin reductase (TrxR) is a selenocysteine-containing enzyme which is responsible - as a part of the thioredoxin system - for maintaining redox homeostasis in cells. It is upregulated in cancerous state as a defense agai...
Targeting the TGF-β signaling pathway for fibrosis therapy: a patent review (2015-2020) [0.03%]
靶向转化生长因子-β信号通路治疗纤维化专利盘点(2015-2020)
Xuanyi Li,Ziang Ding,Zixuan Wu et al.
Xuanyi Li et al.
Introduction: Fibrosis is a serious disease that occurs in many organs, such as kidney, liver and lung. The deterioration of these organs ultimately leads to death. Due to the complex mechanisms of fibrosis, research and ...