Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present) [0.03%]
受体相互作用蛋白激酶1(RIPK1)抑制剂：2018年至今专利文献综述
Lijuan Xu,Wannian Zhang,Chunlin Zhuang
Lijuan Xu
Introduction: RIPK1 is a critical mediator of inflammation and cell death, which is associated with extensive neurodegenerative and inflammatory diseases. Recently, RIPK1 has aroused the interests of pharmaceutical indust...
Current status and patent prospective of lipid nanoparticle for mRNA delivery [0.03%]
脂质纳米颗粒递送mRNA的现状和专利布局分析
Hai-Long Zhang
Hai-Long Zhang
Introduction: Messenger RNA-lipid nanoparticle (mRNA-LNP) delivery is currently a research hotspot in pharmaceutics. LNP has emerged in pharmaceutical industry as popular and effective vehicle for mRNA delivery. It is the...
Purposing plant-derived exosomes-like nanovesicles for drug delivery: patents and literature review [0.03%]
基于植物的类细胞外囊泡纳米载药体系专利及文献分析
Nicola Salvatore Orefice,Rossella Di Raimo,Davide Mizzoni et al.
Nicola Salvatore Orefice et al.
Introduction: How can biotechnology and organic agriculture be fused and promoted simultaneously to overcome the main challenges in drug delivery systems. The role of organic agriculture in future human health treatment s...
Emerging compounds and therapeutic strategies to treat infections from Trypanosoma brucei: an overhaul of the last 5-years patents [0.03%]
东毕吸虫感染的新兴化合物和治疗策略：最近五年专利回顾更新
Francesco Melfi,Simone Carradori,Cristina Campestre et al.
Francesco Melfi et al.
Introduction: Human African Trypanosomiasis is a neglected disease caused by infection from parasites belonging to the Trypanosoma brucei species. Only six drugs are currently available and employed depending on the stage...
Malaria vaccines [0.03%]
疟疾疫苗
Michael Quagliata,Anna Maria Papini,Paolo Rovero
Michael Quagliata
Introduction: Eradication of malaria remains one of the main aims of medicine. Despite progress in malaria treatment, mortality rate remains high, especially in the poorest parts of the world. Therefore, prevention throug...
Ziquan Zhao,Ruitian Dong,Keni Cui et al.
Ziquan Zhao et al.
Introduction: The nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription factor that controls the expression of numerous cytoprotective genes and regulates cellular defense system against oxidative ...
Are patents important indicators of innovation for Chagas disease treatment? [0.03%]
专利是查加斯病治疗创新的重要指标吗？
Andrea Pestana Caroli,Felipe R P Mansoldo,Veronica S Cardoso et al.
Andrea Pestana Caroli et al.
Introduction: Chagas disease is a neglected, endemic disease in 21 countries, spreading to non-endemic countries too. Like other neglected diseases affecting primarily low- and middle-income countries, low investment and ...
Evolution of pediatric pharmaceutical forms for treatment of Hansen's disease (leprosy) [0.03%]
儿童麻风病治疗用药剂型的演变
Jocimar da Silva Santos,Franciely da Costa Alves,Efraim José Dos Santos Júnior et al.
Jocimar da Silva Santos et al.
Introduction: Leprosy is a neglected, infectious, granulomatous and chronic disease caused by the pathological agent Mycobacterium leprae. The course of the disease is more aggressive in patients under 15 years of age, bu...
New designs for HIV-1 integrase inhibitors: a patent review (2018-present) [0.03%]
人类免疫缺陷病毒-1型整合酶抑制剂的新设计(2018年至今)--专利回顾
Yoshiyuki Taoda,Shuichi Sugiyama,Takahiro Seki
Yoshiyuki Taoda
Introduction: Combination antiretroviral therapy (cART) has dramatically reduced morbidity and mortality of HIV-1-infected patients. Integrase strand transfer inhibitors (INSTIs) play an important role as a key drug in cA...
Danni Wang,Xiaohong Li,Guangyue Gong et al.
Danni Wang et al.
Introduction: Kidney-type glutaminase (GLS1), a key enzyme controlling the hydrolysis of glutamine to glutamate to resolve the 'glutamine addiction' of cancer cells, has been shown to play a central role in supporting can...