An updated patent review of anaplastic lymphoma kinase inhibitors (2018-2022) [0.03%]
2018至2022年间血管生成抑制剂类药物的专利分析更新综述
Deyi Ma,Mengrao Guo,Xin Zhai
Deyi Ma
Introduction: Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor superfamily, has emerged as a promising drug target for multiple cancers. Up to now, a total of seven ALK inhibitors have ...
Tizhi Wu,Xiaowei Wu,Yifan Xu et al.
Tizhi Wu et al.
Introduction: The dysregulation of CDK9 protein is greatly related to the proliferation and differentiation of various cancers due to its key role in the regulation of RNA transcription. Moreover, CDK9 inhibition can mark...
Novel therapeutic opportunities for Toxoplasma gondii, Trichomonas vaginalis, and Giardia intestinalis infections [0.03%]
治疗隐孢子虫、阴道毛滴虫和肠小杆虫感染的新疗法
Francesca Arrighi,Arianna Granese,Paola Chimenti et al.
Francesca Arrighi et al.
Introduction: Toxoplasma gondii, Trichomonas vaginalis, and Giardia intestinalis are the causative agents of toxoplasmosis, trichomoniasis, and giardiasis, three important infections threatening human health and affecting...
Guoquan Wan,Huan Feng,Chang Su et al.
Guoquan Wan et al.
Introduction: EZH2 is an important epigenetic regulator that forms the PRC2 complex with SUZ12, EED and RbAp46/48. As the key catalytic subunit of PRC2, EZH2 regulates the trimethylation of histone H3K27, which in turn pr...
The management of Babesia, amoeba and other zoonotic diseases provoked by protozoa [0.03%]
由原生动物传播的巴贝虫病、阿米巴病等兽医寄生虫病的防治措施研究进展
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Introduction: There are 12 protozoan genera that provoke zoonotic disease in humans and animals. We discuss the most common ones with a highlight on Babesia spp and Entamoeba histolytica, also mentioning Toxoplasma gondii...
A patent review of PRMT5 inhibitors to treat cancer (2018 - present) [0.03%]
2018年至今脯氨酰-l-鸟氨酸甲基转移酶5抑制剂的专利分析及其抗肿瘤应用研究进展
Jing Gao,Jie Yang,Shengyu Xue et al.
Jing Gao et al.
Introduction: Protein arginine methyltransferase 5 (PRMT5) belongs to type II arginine methyltransferases. Since PRMT5 plays an essential role in mammalian cells, it can regulate various physiological functions, including...
Elizabeth A Lopes,Maria M M Santos,Mattia Mori
Elizabeth A Lopes
Introduction: The efficacy of current therapeutic warheads in preventing malaria transmission or treating the disease is often hampered by the emergence of drug-resistance. No effective vaccines are available to date, and...
Drugs and nanoformulations for the management of Leishmania infection: a patent and literature review (2015-2022) [0.03%]
利什曼病治疗药物及纳米载体递送系统的专利与文献回顾（2015-2022）
Mariana Verdan,Igor Taveira,Flávia Lima et al.
Mariana Verdan et al.
Introduction: Leishmaniasis is an important disease caused by parasites of the Leishmania. Due to the urgent need for financial incentives and research and development of new anti-Leishmania, a point that stands out is th...
Claudiu T Supuran
Claudiu T Supuran
A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022) [0.03%]
2018至2022年细胞周期蛋白依赖性激酶7（CDK7）抑制剂专利综述（2018-2022）
Markéta Kovalová,Joseph Peter Baraka,Václav Mik et al.
Markéta Kovalová et al.
Introduction: Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of serine/threonine protein kinases and participates in the regulation of the cell cycle and mRNA transcription. CDK7 is emerging as a possible ...