Part-II: an update of Schiff bases synthesis and applications in medicinal chemistry-a patent review (2016-2023) [0.03%]
第二部分:2016-2023年Schiff碱合成及在药物化学中的应用专利回顾更新版本
Hafiza Amna Younus,Faiza Saleem,Abdul Hameed et al.
Hafiza Amna Younus et al.
Introduction: Schiff bases are compounds with characteristic features of azomethine linkage (-C=N-). Schiff bases are capable of coordinating with metal ions via azomethine nitrogen. Schiff base derivatives and their meta...
Junyu Zhang,Jin Wang,Yanchen Li et al.
Junyu Zhang et al.
Introduction: Angiogenesis plays a crucial role in the development of numerous vascular structures and is involved in a variety of physiologic and pathologic processes, including psoriasis, diabetic retinopathy, and espec...
Mudasir Nabi Peerzada,Mohammad Sultan Dar,Saurabh Verma
Mudasir Nabi Peerzada
Introduction: Microtubules are intracellular, filamentous, polymeric structures that extend throughout the cytoplasm, composed of α-tubulin and β-tubulin subunits. They regulate many cellular functions including cell po...
Zhenyu Peng,Leyuan Chen,Manjiang Wang et al.
Zhenyu Peng et al.
Introduction: Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-binding transcription factors that activate genes encoding enzymes required for cholesterol and unsaturated fatty acid synthesis. ...
A patent review on aldehyde dehydrogenase inhibitors: an overview of small molecule inhibitors from the last decade [0.03%]
近十年来醛脱氢酶小分子抑制剂专利分析综述
Biswajit Kundu,Malliga R Iyer
Biswajit Kundu
Introduction: Physiological and pathophysiological effects arising from detoxification of aldehydes in humans implicate the enzyme aldehyde dehydrogenase (ALDH) gene family comprising of 19 isoforms. The main function of ...
Nanoparticles in pancreatic cancer therapy: a detailed and elaborated review on patent literature [0.03%]
纳米颗粒在胰腺癌治疗中的应用:对专利文献的详细综述
Mohini Singh,Bani Kumar Jana,Paulami Pal et al.
Mohini Singh et al.
Introduction: Nanotechnology may open up new avenues for overcoming the challenges of pancreatic cancer therapy as a broad arsenal of anticancer medicines fail to realize their full therapeutic potential in pancreatic duc...
An updated patent review of matrix metalloproteinase (MMP) inhibitors (2021-present) [0.03%]
2021年以来基质金属蛋白酶(MMPs)抑制剂专利分析更新
Suvankar Banerjee,Sandip Kumar Baidya,Nilanjan Adhikari et al.
Suvankar Banerjee et al.
Introduction: Matrix metalloproteinases (MMPs) are strongly interlinked with the progression and mechanisms of several life-threatening diseases including cancer. Thus, novel MMP inhibitors (MMPIs) as promising drug candi...
An updated patent review of GPR40/ FFAR1 modulators (2020 - present) [0.03%]
2020年以来G蛋白偶联受体GPR40/FFAR1调节剂专利进展综述
Qiang Ren,Yiqing Fan,Lixin Yang et al.
Qiang Ren et al.
Introduction: Free fatty acid receptor 1 (FFAR1) is a potential therapeutic target for type 2 diabetes mellitus (T2DM) because it could clinically stimulate insulin release in a glucose-dependent manner without inducing h...
Recent advances on patents of Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH) inhibitors as antimalarial agents [0.03%]
recent advances in the patenting of Plasmodium falciparum dihydroorotate dehydrogenase(pfdhodh)抑制剂抗疟药的研究进展
Pinky Gehlot,Vivek K Vyas
Pinky Gehlot
Introduction: Pyrimidine nucleotides are essential for the parasite's growth and replication. Parasites have only a de novo pathway for the biosynthesis of pyrimidine nucleotides. Dihydroorotate dehydrogenase (DHODH) enzy...
Conjugates of monocyclic β-lactams and siderophore mimetics: a patent evaluation (WO2023023393) [0.03%]
单环β-内酰胺及其类似 siderophore 衍生物的共轭物:专利评估(WO2023023393)
Alen Krajnc,Stanislav Gobec
Alen Krajnc
Introduction: β-Lactams, which include monobactams, remain the most important class of antibiotics worldwide. Aztreonam, the only monobactam in clinical use, has remarkable activity against many Gram-negative bacteria, b...